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FAAH/MAGL-IN-2

Catalog No. T61707 CAS 2765077-82-3

FAAH/MAGL-IN-2, a potent and reversible inhibitor of FAAH and MAGL, demonstrates oral activity and the ability to cross the blood-brain barrier. It exhibits IC50 values of 11 nM for FAAH and 36 nM for MAGL (Ki values of 28 nM and 60 nM, respectively). This compound shows promise for neuropathic pain research, without impairing locomotion [1].

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FAAH/MAGL-IN-2, CAS 2765077-82-3

Pack Size	Availability	Price/USD
25 mg	10-14 weeks	$ 1,520.00
50 mg	10-14 weeks	$ 1,980.00
100 mg	10-14 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

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Description	FAAH/MAGL-IN-2, a potent and reversible inhibitor of FAAH and MAGL, demonstrates oral activity and the ability to cross the blood-brain barrier. It exhibits IC50 values of 11 nM for FAAH and 36 nM for MAGL (Ki values of 28 nM and 60 nM, respectively). This compound shows promise for neuropathic pain research, without impairing locomotion [1].
In vitro	FAAH/MAGL-IN-2 (compound 14) demonstrated a significant neuroprotective effect in a Cell Cytotoxicity Assay using SH-SY5Y cells at concentrations of 1, 3, 10, 30, and 100 μM over a 24-hour incubation period [1].
In vivo	FAAH/MAGL-IN-2, administered at dosages of 10 mg/kg, demonstrates the potential for significant anti-nociceptive effects without impairing motor coordination and locomotor activity. At varying doses (5, 10, 20 mg/kg), it also shows promise in treating neuropathic pain without affecting locomotion. Tolerability and safety assessments reveal that FAAH/MAGL-IN-2, at an oral dose up to 2000 mg/kg in female rats, does not alter liver enzyme activity, signifying its safety at high doses. Additionally, at 20 mg/kg, this compound exhibits favorable oral absorption characteristics. Pharmacokinetic analysis in male Wistar rats, weighing 200–250 g, receiving a 20 mg/kg oral dose, discloses a peak plasma concentration (C max) of 22.04±2.5 μg/mL, occurring at 0.5 hours post-administration, with an area under the curve (AUC 0-t) of 535±1.5 μg min/mL and a half-life (t 1/2) of 20.58 hours, indicating substantial systemic exposure and prolonged circulation time. In neuropathic pain models, both the nerve injury model in rats (CCI model) and studies in 200–250 g male Wistar rats have shown that FAAH/MAGL-IN-2, at dosages of 5, 10, 20 mg/kg administered orally, significantly increases paw withdrawal thresholds and reduces tail flick latency, further supporting its analgesic potential and effective absorption post-oral administration.

Molecular Weight	386.25
Formula	C15H13Cl2N3O3S
CAS No.	2765077-82-3

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

FAAH/MAGL-IN-2 2765077-82-3 inhibitor inhibit

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