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Xanthoxylin

Name: Xanthoxylin
Brand: TargetMol
SKU: T2981
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2981Cas No. 90-24-4

Alias Xanthoxyline, 2'-Hydroxy-4',6'-dimethoxyacetophenone

Xanthoxylin (Xanthoxyline) is a borneol and camphor tasting compound and can be found in a number of food items such as fats and oils, herbs and spices, pomegranate, and sweet orange. Derivatives of Xanthoxylin have antispasmodic activity.

Xanthoxylin

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Purity: 99.58%

Catalog No. T2981Alias Xanthoxyline, 2'-Hydroxy-4',6'-dimethoxyacetophenoneCas No. 90-24-4

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$31	In Stock	In Stock
1 g	$44	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.58%

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Xanthoxylin AI Summary

Xanthoxylin demonstrates a diverse range of bioactivities, including significant cytotoxic effects against various human cancer cell lines. It exhibits cytotoxicity against human 9KB cells, where a concentration of 10 µg/ml leads to a 100.0% cell survival rate, but at 100 µg/ml, the cytotoxicity activity drops to 0.0%. Against HeLa cells, it has an IC50 value of 18,700.0 nM, indicating moderate cytotoxicity, whereas for U937, A549, MIAPaCa2, REH, and HCT116 cells, the IC50 values are all greater than 20,000.0 nM, showing reduced potency. The compound also exhibits high cytotoxicity against HeLa, A549, HT-29, and HL60 cells with IC50 values exceeding 100,000.0 nM. Additionally, Xanthoxylin shows antiviral activity against SARS-CoV-2, with an IC50 value greater than 20,000.0 nM against virus-induced cytotoxicity in VERO-6 cells, indicating weak potency. The compound is active in various biochemical assays, enhancing SMN2 splice variant expression, inhibiting the ERK pathway, inhibiting USP2a and USP1/UAF1, and affecting Cytochrome P450 3A4 as both an activator and inhibitor. Furthermore, it shows inhibition of human tyrosyl-DNA phosphodiesterase 1 (TDP1) with and without CPT, inhibits binding or entry of Lassa and Marburg viruses, and inhibits PLK1-PDB. Lastly, Xanthoxylin robustly inhibits sodium fluorescein uptake in OATP1B3 and OATP1B1-transfected CHO cells at 10 µM, with inhibition percentages of 104.34% and 128.73%, respectively, indicating a strong inhibitory effect on the transport activity of these proteins..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Xanthoxylin (Xanthoxyline) is a borneol and camphor tasting compound and can be found in a number of food items such as fats and oils, herbs and spices, pomegranate, and sweet orange. Derivatives of Xanthoxylin have antispasmodic activity.
Synonyms	Xanthoxyline, 2'-Hydroxy-4',6'-dimethoxyacetophenone

Chemical Properties

Molecular Weight	196.2
Formula	C₁₀H₁₂O₄
Cas No.	90-24-4
Smiles	COC1=CC(O)=C(C(C)=O)C(OC)=C1
Relative Density.	1.172g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27.5 mg/mL (140.16 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.19 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.0968 mL	25.4842 mL	50.9684 mL	254.8420 mL
5 mM	1.0194 mL	5.0968 mL	10.1937 mL	50.9684 mL
10 mM	0.5097 mL	2.5484 mL	5.0968 mL	25.4842 mL
20 mM	0.2548 mL	1.2742 mL	2.5484 mL	12.7421 mL
50 mM	0.1019 mL	0.5097 mL	1.0194 mL	5.0968 mL
100 mM	0.0510 mL	0.2548 mL	0.5097 mL	2.5484 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc