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NGB 2904 (Alias: NGB-2904, NGB2904)
Catalog No. T28167 Copy Product Info
Purity: 98.79%
🥰Excellent
NGB 2904 is a potent and selective antagonist of dopamine D3 receptor (Ki values are 1.4, 217, 223, 642, > 5000, > 10000 and > 10000 nM for D3, D2, 5-HT2, α1, D4, D1 and D5 receptors respectively). NGB2904 potently antagonizes mitogenesis stimulated by quinpirole (IC50 = 6.8 nM).
NGB 2904
Copy Product Info🥰Excellent
Catalog No. T28167
Alias NGB-2904, NGB2904
NGB 2904 is a potent and selective antagonist of dopamine D3 receptor (Ki values are 1.4, 217, 223, 642, > 5000, > 10000 and > 10000 nM for D3, D2, 5-HT2, α1, D4, D1 and D5 receptors respectively). NGB2904 potently antagonizes mitogenesis stimulated by quinpirole (IC50 = 6.8 nM).
Cas No. 189060-98-8
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 2 mg | $34 | In Stock | In Stock | |
| 5 mg | $53 | In Stock | In Stock | |
| 10 mg | $83 | In Stock | In Stock | |
| 25 mg | $166 | In Stock | In Stock | |
| 50 mg | $294 | In Stock | In Stock | |
| 100 mg | $415 | In Stock | In Stock | |
| 500 mg | Preferential | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $69 | In Stock | In Stock |
In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
Batch Information
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Purity:98.79%
Appearance:Solid
Color:White
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Product Introduction
NGB 2904 AI Summary
NGB 2904 has a high selectivity ratio for the human dopamine D3 receptor over the human dopamine D2 receptor, with a selectivity ratio greater than 200.0, suggesting potential bioactivity in selectively targeting the dopamine D3 receptor. Additionally, the compound exhibits antiviral activity against SARS-CoV-2. It inhibits the cytotoxicity of Caco-2 cells with a -7.86% inhibition at a concentration of 10 µM after 48 hours. In VERO-6 cells, NGB 2904 demonstrates an inhibition of -0.02% under similar conditions. Furthermore, it inhibits the SARS-CoV-2 3CL-Pro protease with an inhibition rate of -2.66% at 20 µM, indicating its potential to interfere with viral replication and pathogenesis..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | NGB 2904 is a potent and selective antagonist of dopamine D3 receptor (Ki values are 1.4, 217, 223, 642, > 5000, > 10000 and > 10000 nM for D3, D2, 5-HT2, α1, D4, D1 and D5 receptors respectively). NGB2904 potently antagonizes mitogenesis stimulated by quinpirole (IC50 = 6.8 nM). |
| Targets&IC50 | D3:1.4 nM(Ki), D2:217 nM(Ki), 5-HT2:223 nM(Ki), D1:> 10000 nM(Ki), D5:> 10000 nM(Ki), α1-adrenoceptor:642 nM(Ki), D4:> 5000 nM(Ki) |
| Synonyms | NGB-2904, NGB2904 |
| Molecular Weight | 494.46 |
| Formula | C28H29Cl2N3O |
| Cas No. | 189060-98-8 |
| Smiles | Clc1cccc(N2CCN(CCCCNC(=O)c3ccc-4c(Cc5ccccc-45)c3)CC2)c1Cl |
| Relative Density. | 1.264 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 16.25 mg/mL (32.86 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
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