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NGB 2904

Name: NGB 2904
Brand: TargetMol
SKU: T28167
Price: 415 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28167Cas No. 189060-98-8

Alias NGB-2904, NGB2904

NGB 2904 is a potent and selective antagonist of dopamine D3 receptor (Ki values are 1.4, 217, 223, 642, > 5000, > 10000 and > 10000 nM for D3, D2, 5-HT2, α1, D4, D1 and D5 receptors respectively). NGB2904 potently antagonizes mitogenesis stimulated by quinpirole (IC50 = 6.8 nM).

NGB 2904

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Purity: 98.79%

Catalog No. T28167Alias NGB-2904, NGB2904Cas No. 189060-98-8

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$34	In Stock	In Stock
5 mg	$53	In Stock	In Stock
10 mg	$83	In Stock	In Stock
25 mg	$166	In Stock	In Stock
50 mg	$294	In Stock	In Stock
100 mg	$415	In Stock	In Stock
500 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$69	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.79%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

NGB 2904 AI Summary

NGB 2904 has a high selectivity ratio for the human dopamine D3 receptor over the human dopamine D2 receptor, with a selectivity ratio greater than 200.0, suggesting potential bioactivity in selectively targeting the dopamine D3 receptor. Additionally, the compound exhibits antiviral activity against SARS-CoV-2. It inhibits the cytotoxicity of Caco-2 cells with a -7.86% inhibition at a concentration of 10 µM after 48 hours. In VERO-6 cells, NGB 2904 demonstrates an inhibition of -0.02% under similar conditions. Furthermore, it inhibits the SARS-CoV-2 3CL-Pro protease with an inhibition rate of -2.66% at 20 µM, indicating its potential to interfere with viral replication and pathogenesis..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	NGB 2904 is a potent and selective antagonist of dopamine D3 receptor (Ki values are 1.4, 217, 223, 642, > 5000, > 10000 and > 10000 nM for D3, D2, 5-HT2, α1, D4, D1 and D5 receptors respectively). NGB2904 potently antagonizes mitogenesis stimulated by quinpirole (IC50 = 6.8 nM).
Targets&IC50	α1-adrenoceptor:642 nM(Ki), D4:> 5000 nM(Ki), 5-HT2:223 nM(Ki), D5:> 10000 nM(Ki), D1:> 10000 nM(Ki), D3:1.4 nM(Ki), D2:217 nM(Ki)
Synonyms	NGB-2904, NGB2904

Chemical Properties

Molecular Weight	494.46
Formula	C₂₈H₂₉Cl₂N₃O
Cas No.	189060-98-8
Smiles	Clc1cccc(N2CCN(CCCCNC(=O)c3ccc-4c(Cc5ccccc-45)c3)CC2)c1Cl
Relative Density.	1.264 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 16.25 mg/mL (32.86 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0224 mL	10.1120 mL	20.2241 mL	101.1204 mL
5 mM	0.4045 mL	2.0224 mL	4.0448 mL	20.2241 mL
10 mM	0.2022 mL	1.0112 mL	2.0224 mL	10.1120 mL
20 mM	0.1011 mL	0.5056 mL	1.0112 mL	5.0560 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc