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DFP00173

Name: DFP00173
Brand: TargetMol
SKU: T11014
Price: 66 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T11014Cas No. 672286-03-2

DFP00173 is a potent and selective aquaporin 3 (AQP3) inhibitor, with an IC50 of approximately 0.1-0.4 μM for both mouse and human AQP3. It demonstrates selectivity for AQP3 compared to homologous AQP subtypes AQP7 and AQP9.

DFP00173

🥰Excellent

Purity: 99.53%

Catalog No. T11014Cas No. 672286-03-2

Pack Size	Price	Availability
1 mg	$66	In Stock
5 mg	$160	In Stock
10 mg	$250	In Stock
25 mg	$409	In Stock
50 mg	$571	In Stock
100 mg	$803	In Stock
200 mg	$1,090	In Stock
1 mL x 10 mM (in DMSO)	$176	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.53%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	DFP00173 is a potent and selective aquaporin 3 (AQP3) inhibitor, with an IC50 of approximately 0.1-0.4 μM for both mouse and human AQP3. It demonstrates selectivity for AQP3 compared to homologous AQP subtypes AQP7 and AQP9.
Targets&IC50	AQP3:0.1-0.4 μM
In vitro	DFP00173 inhibits the glycerol permeability of human red blood cells with an IC50 of approximately 0.2 μM.

Chemical Properties

Molecular Weight	332.16
Formula	C₁₁H₇Cl₂N₃O₃S
Cas No.	672286-03-2
Smiles	[O-][N+](=O)c1cc(NC(=O)Nc2c(Cl)cccc2Cl)cs1
Relative Density.	1.702 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 45 mg/mL (135.48 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0106 mL	15.0530 mL	30.1060 mL	150.5299 mL
5 mM	0.6021 mL	3.0106 mL	6.0212 mL	30.1060 mL
10 mM	0.3011 mL	1.5053 mL	3.0106 mL	15.0530 mL
20 mM	0.1505 mL	0.7526 mL	1.5053 mL	7.5265 mL
50 mM	0.0602 mL	0.3011 mL	0.6021 mL	3.0106 mL
100 mM	0.0301 mL	0.1505 mL	0.3011 mL	1.5053 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc