Shopping Cart

Your shopping cart is currently empty

DFP00173

Name: DFP00173
Brand: TargetMol
SKU: T11014
Price: 66 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Catalog No. T11014Cas No. 672286-03-2

DFP00173 is a potent and selective aquaporin 3 (AQP3) inhibitor, with an IC50 of approximately 0.1-0.4 μM for both mouse and human AQP3. It demonstrates selectivity for AQP3 compared to homologous AQP subtypes AQP7 and AQP9.

DFP00173

😃Good

Purity: 99.53%

Catalog No. T11014Cas No. 672286-03-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$66	In Stock	In Stock
5 mg	$160	In Stock	In Stock
10 mg	$250	In Stock	In Stock
25 mg	$409	In Stock	In Stock
50 mg	$571	In Stock	In Stock
100 mg	$803	In Stock	In Stock
200 mg	$1,090	-	In Stock
1 mL x 10 mM (in DMSO)	$176	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

Questions

Batch Information

Select Batch

Purity:99.53%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	DFP00173 is a potent and selective aquaporin 3 (AQP3) inhibitor, with an IC50 of approximately 0.1-0.4 μM for both mouse and human AQP3. It demonstrates selectivity for AQP3 compared to homologous AQP subtypes AQP7 and AQP9.
Targets&IC50	AQP3:0.1-0.4 μM
In vitro	DFP00173 inhibits the glycerol permeability of human red blood cells with an IC50 of approximately 0.2 μM.

Chemical Properties

Molecular Weight	332.16
Formula	C₁₁H₇Cl₂N₃O₃S
Cas No.	672286-03-2
Smiles	[O-][N+](=O)c1cc(NC(=O)Nc2c(Cl)cccc2Cl)cs1
Relative Density.	1.702 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 100 mg/mL (301.06 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.02 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0106 mL	15.0530 mL	30.1060 mL	150.5299 mL
5 mM	0.6021 mL	3.0106 mL	6.0212 mL	30.1060 mL
10 mM	0.3011 mL	1.5053 mL	3.0106 mL	15.0530 mL
20 mM	0.1505 mL	0.7526 mL	1.5053 mL	7.5265 mL
50 mM	0.0602 mL	0.3011 mL	0.6021 mL	3.0106 mL
100 mM	0.0301 mL	0.1505 mL	0.3011 mL	1.5053 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc