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1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea

🥰Excellent
Catalog No. T22424Cas No. 1313019-65-6

Compound SC-1 is a a derivative of the multiple tyrosine kinase inhibitor sorafenib. Compound SC-1 potently inhibits the phosphorylation of STAT3 by blocking STAT3 phosphorylation and activation, and induces apoptosis in hepatocellular carcinoma cell lines[1].

1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea
Other Forms of 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea:

1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea

🥰Excellent
Purity: 99.41%
Catalog No. T22424Cas No. 1313019-65-6
Compound SC-1 is a a derivative of the multiple tyrosine kinase inhibitor sorafenib. Compound SC-1 potently inhibits the phosphorylation of STAT3 by blocking STAT3 phosphorylation and activation, and induces apoptosis in hepatocellular carcinoma cell lines[1].
Pack SizePriceAvailabilityQuantity
1 mg$37In Stock
5 mg$85In Stock
10 mg$137In Stock
25 mg$293In Stock
50 mg$478In Stock
100 mg$685In Stock
200 mg$953In Stock
1 mL x 10 mM (in DMSO)$105In Stock
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Purity:99.41%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
Compound SC-1 is a a derivative of the multiple tyrosine kinase inhibitor sorafenib. Compound SC-1 potently inhibits the phosphorylation of STAT3 by blocking STAT3 phosphorylation and activation, and induces apoptosis in hepatocellular carcinoma cell lines[1].
In vitro
Compound SC-1 (1-10 μM; 48 hours; breast cancer cells) treatment demonstrates dose-dependent suppression of cell viability in all tested breast cancer cells[1]. Compound SC-1 (1-10 μM; 36 hours; breast cancer cells) treatment induces potent apoptotic activity in association with downregulation of p-STAT3 and its downstream proteins cyclin D1 and survivin in a dose-dependent manner in breast cancer cell lines[1].
In vivo
Compound SC-1 showes efficacious antitumor activity and p-STAT3 downregulation in MDA-MB-468 xenograft tumors in vivo[1].
Animal Research
Compound SC-1 (10 mg/kg; oral gavage; daily; for 28 days; Female NCr athymic nude mice (4-6 weeks of age) injected with breast cancer cells) treatment shows efficacious antitumor activity and p-STAT3 downregulation in MDA-MB-468 xenograft tumors[1].
Chemical Properties
Molecular Weight431.8
FormulaC21H13ClF3N3O2
Cas No.1313019-65-6
SmilesFC(F)(F)C1=CC(NC(=O)NC2=CC=C(OC3=CC=C(C=C3)C#N)C=C2)=CC=C1Cl
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 55 mg/mL (127.37 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3159 mL11.5794 mL23.1589 mL115.7943 mL
5 mM0.4632 mL2.3159 mL4.6318 mL23.1589 mL
10 mM0.2316 mL1.1579 mL2.3159 mL11.5794 mL
20 mM0.1158 mL0.5790 mL1.1579 mL5.7897 mL
50 mM0.0463 mL0.2316 mL0.4632 mL2.3159 mL
100 mM0.0232 mL0.1158 mL0.2316 mL1.1579 mL

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Keywords

survivinSTAT3STATSHP-1p-STAT3orallykinaseInhibitorinhibitcyclin-D1Apoptosisanticancer1(4Chloro3(trifluoromethyl)phenyl)3(4(4cyanophenoxy)phenyl)urea1 (4 Chloro 3 (trifluoromethyl)phenyl) 3 (4 (4 cyanophenoxy)phenyl)urea
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