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Anti-Neuropilin-1 Antibody-PE (3Z32)
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Catalog No. TMAY-00058P
Alias VEGF165R, NRP, NP1, Neuropilin-1, neuropilin 1, CD304, BDCA4
Anti-Neuropilin-1 Antibody-PE (3Z32) is a PE-conjugated Mouse antibody targeting Neuropilin-1. Anti-Neuropilin-1 Antibody-PE (3Z32) can be used in FCM.
Anti-Neuropilin-1 Antibody-PE (3Z32)
Anti-Neuropilin-1 Antibody-PE (3Z32)
😃Good
Catalog No. TMAY-00058PAlias VEGF165R, NRP, NP1, Neuropilin-1, neuropilin 1, CD304, BDCA4
Anti-Neuropilin-1 Antibody-PE (3Z32) is a PE-conjugated Mouse antibody targeting Neuropilin-1. Anti-Neuropilin-1 Antibody-PE (3Z32) can be used in FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 T | $105 | 7-10 days | |
| 100 T | $328 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: FCM Reactivity: Human |
| Alias | VEGF165R, NRP, NP1, Neuropilin-1, neuropilin 1, CD304, BDCA4 |
| Ig Type | Mouse IgG1 |
| Clone | 3Z32 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of human NRP1 expression on HUVEC cells. |
| Application | FCM |
| Recommended Dose | 10 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Neuropilin-1 / NRP1 / CD304 (rh Neuropilin-1 / NRP1 / CD304; TMPY-02367; NP_001019799.1; Met1-Lys644) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Research Background | Neuropilin is a type I transmembrane protein and the molecular mass is 120 kDa. Two homologs, Neuropilin-1 and Neuropilin-2, are identified. The primary structure of Neuropilin-1 and Neuropilin-2 is well conserved and is divided into four domains, CUB (a1/a2) domain, FV/FVIII (b1/b2) domain, MAM (c) domain, and (d) domain that contains a transmembrane and a short cytoplasmic region. Neuropilin-1 (NRP1) acts as a receptor for two different extracellular ligands, class 3 semaphorins, and specific isoforms of vascular endothelial growth factor. The functions of NRP1 and NRP2 have been extensively studied in neurons where they act in axon guidance and in endothelial cells where they promote angiogenesis and cell migration. Neuropilin-1 is likely to mediate contacts between the dendritic cells and the T lymphocytes via homotypic interactions and is essential for the initiation of the primary immune response. NRP1 is a co-receptor for VEGF receptor-2 (VEGFR2) that enhances the binding of VEGF165 to VEGFR2 and VEGF165-mediated chemotaxis. NRP1 expression is regulated in EC by tumor necrosis factor-alpha, the transcription factors dHAND and Ets-1, and vascular injury. NRP1 upregulation is positively correlated with the progression of various tumors. Overexpression of NRPI in rat tumor cells results in enlarged tumors and substantially enhanced tumor angiogenesis. On the other hand, soluble NRP1 (sNRP1) is an antagonist of tumor angiogenesis. |
| Conjucates | PE |
| Others Formats | Unconjugated/APC |
| Antibody Types Available | 3 |
| Immunogen | Recombinant Protein: Human Neuropilin-1 / NRP1 / CD304 protein (TMPY-02367) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| Transport | Shipping with blue ice. |
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