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(Rac)-LB-100

Name: (Rac)-LB-100
Brand: TargetMol
SKU: T2068
Price: 59 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2068Cas No. 2061038-65-9

(Rac)-LB-100, a novel Protein Phosphatase 2A (PP2A) inhibitor, sensitizes malignant meningioma cells to the therapeutic effects of radiation

(Rac)-LB-100

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Purity: 99.77%

Catalog No. T2068Cas No. 2061038-65-9

(Rac)-LB-100, a novel Protein Phosphatase 2A (PP2A) inhibitor, sensitizes malignant meningioma cells to the therapeutic effects of radiation

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$59	In Stock	In Stock
2 mg	$85	In Stock	In Stock
5 mg	$133	In Stock	In Stock
10 mg	$190	In Stock	In Stock
25 mg	$328	In Stock	In Stock
50 mg	$492	In Stock	In Stock
100 mg	$717	In Stock	In Stock
500 mg	$1,490	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.77%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	(Rac)-LB-100, a novel Protein Phosphatase 2A (PP2A) inhibitor, sensitizes malignant meningioma cells to the therapeutic effects of radiation
In vitro	(Rac)-LB-100, a small molecular inhibitor of protein phosphatase 2A (PP2A), has been shown to enhance T cell anti-tumor activity through activation of the mTOR signaling pathway.?Herein, Investigated if a treatment strategy consisting of a combination of LB-100 and anti-CAIX CAR-T cell therapy produced a synergistic anti-tumor effect.?LB-100 enhanced anti-CAIX CAR-T cell treatment efficacy in vitro and in vivo.LB-100 in augmenting the cytotoxic activity of anti-CAIX CAR-T cells and underscore the synergistic therapeutic potential of applying combination LB-100 and CAR-T Cell therapy to other solid tumors[1].
Kinase Assay	PP2A activity assays: Cultured pancreatic cancer cells are treated with IC50 of LB-100 for each cell line or equal volume of vehicle for 2 hours, and PP2A activity assays are then performed using Ser/Thr phosphatase assay kit. Cells are lysed with an ultrasonic cell disruptor, and the PP2A concentration is measured using a Ser/Thr phosphatase assay kit according to the instructions. Assays for each cell line are performed in triplicate.
Cell Research	Cytotoxicity is conducted by using a Cell Counting Kit-8. Cells are seeded in 96-well plates with a density of 3000 cells per well and are assessed after treatments following the CCK-8 protocol. Relative cytotoxicity is expressed as a percentage of speci?c controls. (Only for Reference)

Chemical Properties

Molecular Weight	268.31
Formula	C₁₃H₂₀N₂O₄
Cas No.	2061038-65-9
Smiles	CN1CCN(C(C(C2CCC3O2)C3C(O)=O)=O)CC1
Relative Density.	no data available

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: < 1 mg/mL (insoluble or slightly soluble)

H2O: 49 mg/mL (182.62 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	3.7270 mL	18.6352 mL	37.2703 mL	186.3516 mL
5 mM	0.7454 mL	3.7270 mL	7.4541 mL	37.2703 mL
10 mM	0.3727 mL	1.8635 mL	3.7270 mL	18.6352 mL
20 mM	0.1864 mL	0.9318 mL	1.8635 mL	9.3176 mL
50 mM	0.0745 mL	0.3727 mL	0.7454 mL	3.7270 mL
100 mM	0.0373 mL	0.1864 mL	0.3727 mL	1.8635 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc