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BMS-605541

Name: BMS-605541
Brand: TargetMol
SKU: T26852
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T26852Cas No. 639858-32-5

Alias BMS605541, BMS 605541

BMS-605541 is a potent and selective inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2) kinase activity(Ki=49 nM).

BMS-605541

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Purity: 98.71%

Catalog No. T26852Alias BMS605541, BMS 605541Cas No. 639858-32-5

BMS-605541 is a potent and selective inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2) kinase activity(Ki=49 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$31	In Stock	In Stock
25 mg	$66	In Stock	In Stock
50 mg	$107	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.71%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

BMS-605541 AI Summary

BMS-605541 exhibits a diverse range of bioactivities, notably inhibiting human ERG with an IC50 of 16600.0 nM. It demonstrates antiproliferative activity against L2987 cells with an IC50 greater than 2500.0 nM and VEGF-stimulated HUVEC with an IC50 of 25.0 nM. Additionally, BMS-605541 has shown efficacy in inhibiting tumor growth in athymic mice xenografted with HCT116 and L2987 across various doses, demonstrating notable TGI percentages. It also inhibits multiple kinases, including c-kit, PDGFR beta, VEGFR1, FLK1, and VEGFR2, each with distinct IC50 values. Pharmacokinetic properties of BMS-605541 have been characterized in cynomolgus monkey, Sprague-Dawley rat, and Balb/C mouse, covering parameters such as bioavailability, volume of distribution, clearance, half-life, mean residence time, AUC, Tmax, and Cmax..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	BMS-605541 is a potent and selective inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2) kinase activity(Ki=49 nM).
Targets&IC50	PDGFRβ:200 nM, VEGFR1:400 nM, VEGFR2:23 nM, VEGFR2:49 nM (Ki), FLK1:40 nM
Synonyms	BMS605541, BMS 605541

Chemical Properties

Molecular Weight	401.43
Formula	C₁₉H₁₇F₂N₅OS
Cas No.	639858-32-5
Smiles	Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1
Relative Density.	1.44 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 36.1 mg/mL (89.93 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.98 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4911 mL	12.4555 mL	24.9109 mL	124.5547 mL
5 mM	0.4982 mL	2.4911 mL	4.9822 mL	24.9109 mL
10 mM	0.2491 mL	1.2455 mL	2.4911 mL	12.4555 mL
20 mM	0.1246 mL	0.6228 mL	1.2455 mL	6.2277 mL
50 mM	0.0498 mL	0.2491 mL	0.4982 mL	2.4911 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc