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GSK8612

Name: GSK8612
Brand: TargetMol
SKU: T5540
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5540Cas No. 2361659-62-1

GSK8612 is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1, pIC50: 6.8).

GSK8612

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Purity: 99.8%

Catalog No. T5540Cas No. 2361659-62-1

GSK8612 is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1, pIC50: 6.8).

Pack Size	Price	Availability
1 mg	$39	In Stock
2 mg	$54	In Stock
5 mg	$84	In Stock
10 mg	$133	In Stock
25 mg	$226	In Stock
50 mg	$397	In Stock
100 mg	$597	In Stock
1 mL x 10 mM (in DMSO)	$97	In Stock

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Batch Information

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Purity:99.8%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	GSK8612 is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1, pIC50: 6.8).
Targets&IC50	TBK1:6.8 (pIC50)
In vitro	In cellular assays, GSK8612 inhibited toll-like receptor (TLR)3-induced interferon regulatory factor (IRF)3 phosphorylation in Ramos cells and type I interferon (IFN) secretion in primary human mononuclear cells. In THP1 cells, GSK8612 was able to inhibit secretion of interferon-beta (IFNβ) in response to dsDNA and cGAMP, the natural ligand for STING.

Chemical Properties

Molecular Weight	520.33
Formula	C₁₇H₁₇BrF₃N₇O₂S
Cas No.	2361659-62-1
Smiles	Cc1nn(CC(F)(F)F)cc1Nc1ncc(Br)c(NCc2ccc(cc2)S(N)(=O)=O)n1
Relative Density.	1.74 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: Insoluble

DMSO: 34 mg/mL (65.34 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.84 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9219 mL	9.6093 mL	19.2186 mL	96.0929 mL
5 mM	0.3844 mL	1.9219 mL	3.8437 mL	19.2186 mL
10 mM	0.1922 mL	0.9609 mL	1.9219 mL	9.6093 mL
20 mM	0.0961 mL	0.4805 mL	0.9609 mL	4.8046 mL
50 mM	0.0384 mL	0.1922 mL	0.3844 mL	1.9219 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc