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ONO-5334

Name: ONO-5334
Brand: TargetMol
SKU: T16394
Price: 165 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16394Cas No. 868273-90-9

ONO-5334 is a selective, orally active and potent histone K inhibitor with anti-SAR-COV-2 and anti-bone resorption activity for the study of osteoporosis.

ONO-5334

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Purity: 99.60%

Catalog No. T16394Cas No. 868273-90-9

ONO-5334 is a selective, orally active and potent histone K inhibitor with anti-SAR-COV-2 and anti-bone resorption activity for the study of osteoporosis.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$165	-	In Stock
5 mg	$413	-	In Stock
10 mg	$662	-	In Stock
25 mg	$1,120	-	In Stock
50 mg	$1,490	-	In Stock
1 mL x 10 mM (in DMSO)	$455	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.60%

Appearance:Solid

Color:White to Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	ONO-5334 is a selective, orally active and potent histone K inhibitor with anti-SAR-COV-2 and anti-bone resorption activity for the study of osteoporosis.
Targets&IC50	Cathepsin K (rabbit):0.049 nM (Ki), Cathepsin K (rat):0.85 nM (Ki), Cathepsin K (human):0.10 nM (Ki)
In vitro	ONO-5334 inhibits human cathepsin S, L, and B, and porcine calpain Ι and II (Ki: 0.83 nM, 1.7 nM, 32 nM, 82 nM, and 69 nM, respectively). ONO-5334 (0.1-1 μM; 24 hours) also inhibits human osteoclast-mediated bone resorption, effectively decreasing the osteoclast-mediated release of CTX from bone slices in a dose-dependent manner[1].
In vivo	ONO-5334 (oral; 0.3-30 mg/kg; 7 consecutive days) at doses of 3 mg/kg or 30 mg/kg significantly reduced CTX (bone resorption marker) concentrations.ONO-5334 (oral; 0.12-15 mg/kg; single dose) dose-dependently reduced PTHrP-induced elevation of plasma calcium, with a significant effect at 15 mg/kg (86% reduction). It also reduced the PTHrP-induced increase in plasma CTX levels in TPTX rats by 90% at 15 mg/kg. On day 7, ONO-5334 (3 mg/kg and 30 mg/kg) reduced serum CTX concentrations by 62% and 79%, respectively[1].

Chemical Properties

Molecular Weight	438.58
Formula	C₂₁H₃₄N₄O₄S
Cas No.	868273-90-9
Smiles	C[C@@H]1CS\C(=N/NC(=O)C(=O)[C@@H](NC(=O)C2CCCCCC2)C2CCOCC2)N1C
Relative Density.	1.36 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (68.4 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2801 mL	11.4004 mL	22.8009 mL	114.0043 mL
5 mM	0.4560 mL	2.2801 mL	4.5602 mL	22.8009 mL
10 mM	0.2280 mL	1.1400 mL	2.2801 mL	11.4004 mL
20 mM	0.1140 mL	0.5700 mL	1.1400 mL	5.7002 mL
50 mM	0.0456 mL	0.2280 mL	0.4560 mL	2.2801 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc