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CCG-1423

Name: CCG-1423
Brand: TargetMol
SKU: T2014
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2014Cas No. 285986-88-1

Alias CCG1423

CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.

CCG-1423

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Purity: 99.80%

Catalog No. T2014Alias CCG1423Cas No. 285986-88-1

CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$32	In Stock	In Stock
10 mg	$52	In Stock	In Stock
25 mg	$97	In Stock	In Stock
50 mg	$165	In Stock	In Stock
100 mg	$275	In Stock	In Stock
200 mg	$428	In Stock	In Stock
500 mg	$695	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.80%

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.
Targets&IC50	LRRK2 (G2019S):1.85 nM, LRRK2 (WT):1.28 nM
In vivo	In H9c2 cells, CCG-1423 inhibits MRTF nuclear localization and completely blocks the activity of STARS proximal reporter genes. It also suppresses TGF-β-induced fibrogenesis in human colon myofibroblasts. Under the influence of CCG-1423 and LY294002, mouse embryonic stem cells differentiate into the mesendoderm. In melanoma cells (A375M2 and SK-Mel-147) overexpressing RhoC, CCG-1423 selectively inhibits cell proliferation.
Cell Research	Cells in normal culture medium are plated (2,000 per well) in a 96-well plate coated with laminin. After attachment, the medium is replaced with serum-free medium (0% FBS) with 30 μmol/L LPA with or without 300 nM CCG-1423. Fresh LPA with or without CCG-1423 is added at day 5 to ensure that LPA and compound are present throughout the experiment. On day 8, WST-1 reagent is added to the wells for 1 h and absorbance at 450 nm is read using a Victor plate reader.(Only for Reference)
Synonyms	CCG1423

Chemical Properties

Molecular Weight	454.75
Formula	C₁₈H₁₃ClF₆N₂O₃
Cas No.	285986-88-1
Smiles	CC(ONC(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C(=O)Nc1ccc(Cl)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 4 mg/mL (8.8 mM), Heating is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 245 mg/mL (538.76 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.26 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1990 mL	10.9951 mL	21.9901 mL	109.9505 mL
5 mM	0.4398 mL	2.1990 mL	4.3980 mL	21.9901 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2199 mL	1.0995 mL	2.1990 mL	10.9951 mL
20 mM	0.1100 mL	0.5498 mL	1.0995 mL	5.4975 mL
50 mM	0.0440 mL	0.2199 mL	0.4398 mL	2.1990 mL
100 mM	0.0220 mL	0.1100 mL	0.2199 mL	1.0995 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc