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β-Apo-13-carotenone

Name: β-Apo-13-carotenone
Brand: TargetMol
SKU: T13431
Rating: 4.5 (1 reviews)

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Catalog No. T13431Cas No. 17974-57-1

Alias D'Orenone

β-Apo-13-carotenone is a naturally occurring β-apocarotenoid, and is a RXRα antagonist.

β-Apo-13-carotenone

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Catalog No. T13431Alias D'OrenoneCas No. 17974-57-1

β-Apo-13-carotenone is a naturally occurring β-apocarotenoid, and is a RXRα antagonist.

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Product Introduction

Bioactivity

Description	β-Apo-13-carotenone is a naturally occurring β-apocarotenoid, and is a RXRα antagonist.
In vitro	In homogenates of intestinal mucosa of rat, β-apo-13-Carotenone is identified as enzymatic cleavage products of β-carotene. β-apo-13-carotenone is antagonize the activation of RXRα by 9-cis-retinoic acid and is effective at concentrations as low as 1nM. Molecular modeling studies reveal that β-apo-13-carotenone makes molecular interactions like an antagonist of RXRα[1]. β-apo-13-carotenone competes for 9cRA binding to RXRα with an affinity (7–8 nM) identical to 9cRA itself. β-apo-13-carotenone antagonizes 9cRA activation of full-length hRXRα with a similar efficiency as the known antagonist UVI3003. β-apo-13-carotenone induces formation of the RXRα transcriptionally silent tetramer but does not inhibit coactivator recruitment to the isolated LBD[2].
Synonyms	D'Orenone

Chemical Properties

Molecular Weight	258.4
Formula	C₁₈H₂₆O
Cas No.	17974-57-1
Smiles	CC(=O)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C
Relative Density.	0.945 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 33.33 mg/mL (128.99 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (7.74 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8700 mL	19.3498 mL	38.6997 mL	193.4985 mL
5 mM	0.7740 mL	3.8700 mL	7.7399 mL	38.6997 mL
10 mM	0.3870 mL	1.9350 mL	3.8700 mL	19.3498 mL
20 mM	0.1935 mL	0.9675 mL	1.9350 mL	9.6749 mL
50 mM	0.0774 mL	0.3870 mL	0.7740 mL	3.8700 mL
100 mM	0.0387 mL	0.1935 mL	0.3870 mL	1.9350 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc