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Anti-Dysferlin interacting protein 1 Polyclonal Antibody
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Catalog No. TMAB-05370
Anti-Dysferlin interacting protein 1 Polyclonal Antibody is a Rabbit antibody targeting Dysferlin interacting protein 1. Anti-Dysferlin interacting protein 1 Polyclonal Antibody can be used in WB.
Anti-Dysferlin interacting protein 1 Polyclonal Antibody
Anti-Dysferlin interacting protein 1 Polyclonal Antibody
😃Good
Catalog No. TMAB-05370
Anti-Dysferlin interacting protein 1 Polyclonal Antibody is a Rabbit antibody targeting Dysferlin interacting protein 1. Anti-Dysferlin interacting protein 1 Polyclonal Antibody can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Dysferlin interacting protein 1 Polyclonal Antibody is a Rabbit antibody targeting Dysferlin interacting protein 1. Anti-Dysferlin interacting protein 1 Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Mouse,Rat (predicted:Human,Dog,Cow,Horse,Sheep) |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Dysferlin is a muscle-specific protein that is essential for normal muscle function and development (1). Mutations in the human dysferlin gene, DYSF, which maps to chromosome 2p13.3-p13.1, are associated with limb girdle muscular dystrophy-2B (LGMD-2B) and a related, adult-onset, distal dystrophy known as Miyoshi myopathy (MM) (1,2). Dysferlin localizes to the muscle fiber membrane, but is absent in MM and LGMD-2B muscle (1,3). Dysferlin is detected in 5-6 week embryos, when limbs begin to form regional differentiation (3). Although it is not essential for initial myogenesis, dysferlin appears to be critical for sustained normal function in mature muscle (1). It has been suggested that the absence of dysferlin during development gives rise to the disease phenotype in adulthood (3). Identical mutations in the dysferlin gene can produce more than one myopathy phenotype, indicating that additional genes and/or other factors are also involved in the clinical phenotype (4,5). The DYSF gene has no homology to any other known mammalian gene, but the protein product is related to the spermatogenesis factor fer-1 of Caenorhabditis elegans. The name ‘dysferlin’ combines the role of the gene in producing muscular dystrophy with its homology to C. elegans (6). |
| Immunogen | KLH conjugated synthetic peptide: human Dysferlin interacting protein 1 |
| Antigen Species | Human |
| Gene Name | PPP1R27 |
| Gene ID | |
| Protein Name | Protein phosphatase 1 regulatory subunit 27 |
| Uniprot ID | |
| Function | Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. |
| Molecular Weight | Theoretical: 17 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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