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1-Methyl-L-histidine

Name: 1-Methyl-L-histidine
Brand: TargetMol
SKU: T4934
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4934Cas No. 332-80-9

Alias Nτ-Methyl-L-histidine, 3-(1-Methylimidazol-4-yl)-L-alanine

1-Methyl-L-histidine (3-(1-Methylimidazol-4-yl)-L-alanine) is a natural but non-proteinogenic amino acid; employed as index of muscle protein breakdown.

1-Methyl-L-histidine

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Purity: 99.83%

Catalog No. T4934Alias Nτ-Methyl-L-histidine, 3-(1-Methylimidazol-4-yl)-L-alanineCas No. 332-80-9

1-Methyl-L-histidine (3-(1-Methylimidazol-4-yl)-L-alanine) is a natural but non-proteinogenic amino acid; employed as index of muscle protein breakdown.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$30	In Stock	In Stock
10 mg	$48	In Stock	In Stock
25 mg	$73	In Stock	In Stock
50 mg	$98	In Stock	In Stock
100 mg	$143	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.83%

Color:White

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Product Introduction

1-Methyl-L-histidine AI Summary

1-Methyl-L-histidine has been studied for its bioactivity and potential involvement in various biological processes. Notably, it acts as an inhibitor of the LAT1 transporter, as evidenced by its cis-inhibition of [3H]-gabapentin uptake with an IC50 of 190,000.0 nM and a 70.0% inhibition at 200 µM. Furthermore, it induces [3H]-gabapentin efflux with 85.0% activity relative to L-phenylalanine at the same concentration. However, 1-Methyl-L-histidine exhibited no inhibition (0.0%) of histidine decarboxylase in Sprague-Dawley rat stomach during assays that measured 14CO2 production using L-histidine-carboxyl-14C as a substrate. These findings highlight the compound’s specific bioactivity in modulating LAT1 transporter functions, while it remains inactive against histidine decarboxylase..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1-Methyl-L-histidine (3-(1-Methylimidazol-4-yl)-L-alanine) is a natural but non-proteinogenic amino acid; employed as index of muscle protein breakdown.
Synonyms	Nτ-Methyl-L-histidine, 3-(1-Methylimidazol-4-yl)-L-alanine

Chemical Properties

Molecular Weight	169.18
Formula	C₇H₁₁N₃O₂
Cas No.	332-80-9
Smiles	Cn1cnc(C[C@H](N)C(O)=O)c1
Relative Density.	1.37 g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: Slightly soluble

H2O: 100 mg/mL (591.09 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	5.9109 mL	29.5543 mL	59.1086 mL	295.5432 mL
5 mM	1.1822 mL	5.9109 mL	11.8217 mL	59.1086 mL
10 mM	0.5911 mL	2.9554 mL	5.9109 mL	29.5543 mL
20 mM	0.2955 mL	1.4777 mL	2.9554 mL	14.7772 mL
50 mM	0.1182 mL	0.5911 mL	1.1822 mL	5.9109 mL
100 mM	0.0591 mL	0.2955 mL	0.5911 mL	2.9554 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc