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Dapagliflozin ((2S)-1,2-propanediol, hydrate)

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Catalog No. T4460Cas No. 960404-48-2
Alias Dapagliflozin propanediol monohydrate, BMS-512148 (2S)-1,2-propanediol, hydrate

Dapagliflozin ((2S)-1,2-propanediol, hydrate) (BMS-512148 (2S)-1,2-propanediol, hydrate) is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2), in development for treating type 2 diabetes mellitus (T2DM). It inhibits SGLT2, responsible for at least 90% of glucose reabsorption in the kidney.

Dapagliflozin ((2S)-1,2-propanediol, hydrate)
Other Forms of Dapagliflozin ((2S)-1,2-propanediol, hydrate):

Dapagliflozin ((2S)-1,2-propanediol, hydrate)

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Purity: 99.94%
Catalog No. T4460Alias Dapagliflozin propanediol monohydrate, BMS-512148 (2S)-1,2-propanediol, hydrateCas No. 960404-48-2
Dapagliflozin ((2S)-1,2-propanediol, hydrate) (BMS-512148 (2S)-1,2-propanediol, hydrate) is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2), in development for treating type 2 diabetes mellitus (T2DM). It inhibits SGLT2, responsible for at least 90% of glucose reabsorption in the kidney.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$37In StockIn Stock
25 mg$44In StockIn Stock
50 mg$56In StockIn Stock
100 mg$70In StockIn Stock
500 mg$170In StockIn Stock
1 mL x 10 mM (in DMSO)$30In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.94%
Color:White
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Product Introduction

Bioactivity
Description
Dapagliflozin ((2S)-1,2-propanediol, hydrate) (BMS-512148 (2S)-1,2-propanediol, hydrate) is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2), in development for treating type 2 diabetes mellitus (T2DM). It inhibits SGLT2, responsible for at least 90% of glucose reabsorption in the kidney.
Targets&IC50
SGLT2:
In vitro
Dapagliflozin (2S)-1,2-propanediol, hydrate is the S-enantiomer of Dapagliflozin 1,2-propanediol, hydrate. Dapagliflozin inhibits sodium/glucose cotransporter 2 (SGLT2), which results in excretion of glucose into the urine.
SynonymsDapagliflozin propanediol monohydrate, BMS-512148 (2S)-1,2-propanediol, hydrate
Chemical Properties
Molecular Weight502.98
FormulaC24H35ClO9
Cas No.960404-48-2
SmilesO.O[C@H]1[C@H](O)[C@@H](O)[C@@H](O[C@@H]1CO)c3ccc(Cl)c(Cc2ccc(OCC)cc2)c3.C[C@H](O)CO
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (99.41 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.98 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9882 mL9.9408 mL19.8815 mL99.4075 mL
5 mM0.3976 mL1.9882 mL3.9763 mL19.8815 mL
10 mM0.1988 mL0.9941 mL1.9882 mL9.9408 mL
20 mM0.0994 mL0.4970 mL0.9941 mL4.9704 mL
50 mM0.0398 mL0.1988 mL0.3976 mL1.9882 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Sodium-dependent glucose cotransportersSGLT2SGLTInhibitorinhibitDapagliflozin propanediol MonohydrateDapagliflozin propanediolDapagliflozin (1,2-propanediol, hydrate)Dapagliflozin ((2S)1,2propanediol, hydrate)Dapagliflozin ((2S) 1,2 propanediol, hydrate)BMS-512148 1,2-propanediol, Hydrate
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