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Immunology/Inflammation

Aryl Hydrocarbon Receptor

Immunology/Inflammation related

NOD-like Receptor (NLR)

Prostaglandin Receptor

Reactive Oxygen Species

Thrombopoietin Receptor

Mucin

Mucins (Mucin, MUC) are high molecular weight glycoproteins produced and secreted by epithelial cells, with mucus as their main component. Based on their functions, mucins can be divided into two categories: membrane-bound mucins and secreted mucins. Membrane-bound mucins include MUC1, MUC3A, MUC3B, MUC4, MUC12, MUC13, MUC14, MUC15, MUC16, MUC17, MUC20, MUC21, and MUC22, while secreted mucins include MUC2, MUC5AC, MUC5B, MUC6, MUC7, MUC8, MUC9, and MUC19. Abnormal mucin expression or function can lead to various diseases, including respiratory and gastrointestinal disorders, as well as certain types of cancer.

Filter HomeSignaling PathwaysImmunology/InflammationMucin

Gatipotuzumab

T783181264737-26-9

Gatipotuzumab (PankoMab) is a novel humanized monoclonal antibody conjugated to the tumor-associated epitope of mucin 1 (TA-MUC1) with potential anti-tumor activity for the study of recurrent epithelial ovarian cancer.

$277

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Clivatuzumab MMAE

T9901A-213

Clivatuzumab MMAE is an ADC consisting of a humanized monoclonal antibody against MUC1 (mucin) and the anti-mitotic cytotoxin MMAE for pancreatic cancer.

$1,690

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Clivatuzumab

T771911622075-09-5

Clivatuzumab is a humanized anti-myxinomab, which can target the MUC1 epitope highly expressed on the surface of most pancreatic cancer cells, and has a good therapeutic effect on a variety of tumor cells.

$157

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Guaifenesin

T073993-14-1

Guaifenesin (Guaiphenesin) is an expectorant that also has some muscle relaxing action. It is used in many cough preparations.

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Fudosteine

T148113189-98-5

Fudosteine is a novel mucoactive agent and a MUC5AC mucin hypersecretion inhibitor.

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Gefarnate

T709951-77-4

Gefarnate is a synthetic compound used for the treatment of gastric ulcers,and also used in the treatment of dry eye syndrome.

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Sofituzumab

T782851615692-28-8

Sofituzumab is a humanised monoclonal antibody targeting the MUC16 protein, commonly used in the synthetic ADC Sofituzumab vedotin, which can be used to treat ovarian cancer and pancreatic cancer.

$423

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Minretumomab

T81793195189-17-4

Minretumomab (CC-49) is a mouse monoclonal antibody targeting TAG-72 (tumour-associated glycoprotein 72), optimised from the B72.3 antibody, and can be used for research into breast cancer, colon cancer, lung cancer, and pancreatic cancer.

$247

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M0324

T9901A-749

M0324 is a novel MUC-1 conditional CD40 agonist composed of an anti-MUC-1 IgG and two identical CD40-targeting camelid VHH domains, designed to selectively activate immune cells in the context of tumor cells with high MUC-1 expression.

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Anti-CCL2 (Carlumab)-MC-Vc-PAB-DMEA-PEG2-Duocarmycin SA

T9901A-1107

Anti-CCL2 (Carlumab)-MC-Vc-PAB-DMEA-PEG2-Duocarmycin SA is an antibody-drug conjugate (ADC) composed of the humanized anti-CCL2 (chemokine ligand 2) antibody Carlumab, linked with the MC-Vc-PAB-DMEA-PEG2 connector and the DNA alkylator Duocarmycin SA. This compound is utilized in cancer research.

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Surzebiclimab

T78334

Surzebiclimab (BGB-A425), a humanized variant IgG1 monoclonal antibody, targets and binds with high affinity (K D = 0.36 nM) and specificity to the extracellular domain of T-cell immunoglobulin and mucin-domain containing-3 (TIM-3). This compound is utilized in cancer research [1].

$290

2-4 weeks

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TAB-004

T9901A-1037

TAB-004 is a human monoclonal antibody targeting MUC1. It specifically identifies the tMUC1 present in all major subtypes of breast cancer without affecting normal breast epithelial cells. Additionally, TAB-004 is applicable for research on triple-negative breast cancer (TNBC).

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BTH1704

T9901A-1057

BTH1704 is a human monoclonal antibody targeting MUC1. It facilitates the killing of iC3b-opsonized tumor cells by leukocytes triggered by PGG. BTH1704 is applicable in studies on pancreatic cancer and breast cancer.

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Ac5GalNTGc

T855461334320-77-2

Ac5GalNTGc, an analog of hexosamine, inhibits mucin-type O-linked glycosylation biosynthesis [1].

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10-14 weeks

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Fexlamose

T2061161285607-08-0

Fexlamose is an interventional nebulization solution with mucolytic properties, intended for research in chronic obstructive pulmonary disease (COPD).

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10-14 weeks

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AR20.5

T9901A-991

AR20.5 is a human monoclonal antibody targeting MUC1. It enhances the number of activated CD8 T cells, CD3+CD4−CD8− (DN) T cells, and mature dendritic cells in mice with pancreatic tumors. AR20.5 is applicable for research into anti-pancreatic cancer immunity.

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MUC5AC motif peptide

TP1834

MUC5AC motif peptide, a 16-amino acid fragment of mucin 5, is a key component in the study of glycoproteins and their biological functions.

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Ubletamig

T9901A-8583008247-27-3

Ubletamig is a humanized IgG4κ monoclonal antibody that targets MUC16.

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MUC1, mucin core

T38976149205-73-2

MUC1, mucin core is a type I transmembrane glycoprotein that is characterized by its overexpression and abnormal glycosylation in carcinoma cells. It specifically binds to domain 1 of ICAM-1.

$224

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