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Atracurium besylate

Name: Atracurium besylate
Brand: TargetMol
SKU: T6397
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6397Cas No. 64228-81-5

Alias Tracrium, BW-33A, 51W89

Atracurium besylate (51W89) is a non-depolarizing neuromuscular blocking agent with short duration of action. Its lack of significant cardiovascular effects and its lack of dependence on good kidney function for elimination provide clinical advantage over alternate non-depolarizing neuromuscular blocking agents.

Atracurium besylate

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Purity: 99.71%

Catalog No. T6397Alias Tracrium, BW-33A, 51W89Cas No. 64228-81-5

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$30	In Stock	In Stock
25 mg	$44	In Stock	In Stock
50 mg	$61	In Stock	In Stock
100 mg	$102	In Stock	In Stock
200 mg	$157	In Stock	In Stock
500 mg	$252	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.71%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Atracurium besylate AI Summary

Atracurium besylate exhibits bioactivities as a potent inhibitor of human tyrosyl-DNA phosphodiesterase 1 (TDP1) in various cell assays, effective in the absence and presence of CPT. It also demonstrates inhibition of Plasmodium falciparum proliferation across multiple strains, including 3D7, DD2, and HB3, with potencies ranging from 0.2 nM to 3308.8 nM. Additionally, Atracurium besylate inhibits cell viability in Vero E6 cells infected with SARS-CoV-2 (strain BavPat1), showing an inhibition index of 0.8693. However, it shows no significant inhibitory activity against human BSEP, MRP2, MRP3, and MRP4 transporters (IC50 values >133000.0 nM). Furthermore, it demonstrates neuromuscular blocking activity, as evidenced by reducing electrically-induced twitches and inducing flaccid paralysis in Wistar rat tibialis muscle and chicks; these effects can be reversed with physostigmine. The compound’s potency is underscored by its ED50 value, onset time, and duration of muscle block and relaxation in the respective assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Atracurium besylate (51W89) is a non-depolarizing neuromuscular blocking agent with short duration of action. Its lack of significant cardiovascular effects and its lack of dependence on good kidney function for elimination provide clinical advantage over alternate non-depolarizing neuromuscular blocking agents.
Synonyms	Tracrium, BW-33A, 51W89

Chemical Properties

Molecular Weight	1243.49
Formula	C₆₅H₈₂N₂O₁₈S₂
Cas No.	64228-81-5
Smiles	[O-]S(=O)(=O)c1ccccc1.COc1ccc(CC2c3cc(OC)c(OC)cc3CC[N+]2(C)CCC(=O)OCCCCCOC(=O)CC[N+]2(C)CCc3cc(OC)c(OC)cc3C2Cc2ccc(OC)c(OC)c2)cc1OC.[O-]S(=O)(=O)c1ccccc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (48.25 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (1.61 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8042 mL	4.0209 mL	8.0419 mL	40.2094 mL
5 mM	0.1608 mL	0.8042 mL	1.6084 mL	8.0419 mL
10 mM	0.0804 mL	0.4021 mL	0.8042 mL	4.0209 mL
20 mM	0.0402 mL	0.2010 mL	0.4021 mL	2.0105 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc