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3-Hydroxyisobutyric acid
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Synonyms:
Catalog No. T19619 Copy Product Info
Purity: 95%
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3-Hydroxyisobutyric acid is an intermediate metabolite in the pathways of L-valine and thymine metabolism and can be detected in urine. 3-Hydroxyisobutyric acid functions as a secreted mediator of endothelial cell fatty acid transport and insulin resistance. 3-Hydroxyisobutyric acid additionally inhibits key enzymes involved in energy metabolism within the cerebral cortex of young rats. The levels of 3-Hydroxyisobutyric acid are closely associated with multiple pathological conditions, including 3-hydroxyisobutyric aciduria, diabetes, and ketoacidosis. 3-Hydroxyisobutyric acid is therefore valuable for metabolic disease, endocrinology, and mitochondrial energy metabolism investigations.
Cas No. 2068-83-9
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 mg | $29 | - | In Stock | |
| 10 mg | $44 | - | In Stock | |
| 25 mg | $85 | - | In Stock | |
| 50 mg | $139 | - | In Stock | |
| 100 mg | $222 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $30 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
Batch Information
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Purity:95%
Appearance:Liquid
Color:Transparent
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 3-Hydroxyisobutyric acid is an intermediate metabolite in the pathways of L-valine and thymine metabolism and can be detected in urine. 3-Hydroxyisobutyric acid functions as a secreted mediator of endothelial cell fatty acid transport and insulin resistance. 3-Hydroxyisobutyric acid additionally inhibits key enzymes involved in energy metabolism within the cerebral cortex of young rats. The levels of 3-Hydroxyisobutyric acid are closely associated with multiple pathological conditions, including 3-hydroxyisobutyric aciduria, diabetes, and ketoacidosis. 3-Hydroxyisobutyric acid is therefore valuable for metabolic disease, endocrinology, and mitochondrial energy metabolism investigations. |
| In vitro | 3-Hydroxyisobutyric acid (0.1–1 mM) significantly suppresses the activities of respiratory chain complexes I–III, mitochondrial creatine kinase, total creatine kinase and Na⁺,K⁺-ATPase in rat cerebral cortex homogenates[1]. |
| Molecular Weight | 104.10 |
| Formula | C4H8O3 |
| Cas No. | 2068-83-9 |
| Smiles | O=C(O)C(C)CO |
| Relative Density. | 1.195g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 50.00 mg/mL (480.31 mM), Sonication is recommended. DMSO: Soluble | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
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Related Tags: 3-Hydroxyisobutyric acid chemical structure | 3-Hydroxyisobutyric acid in vitro | 3-Hydroxyisobutyric acid formula | 3-Hydroxyisobutyric acid molecular weight
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