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TargetMol | Compound Library

Natural Product Library for HTS

Catalog No. L6000

Natural products are compounds produced by organisms in nature. Their structures and functions have been selected and optimized during the long evolutionary process of nature, resulting in highly diverse structures through different processes such as oxidation and reduction, rearrangement reaction, cationic cyclization, condensation reactions, and pericyclic reactions.

These unique chemical structures endow natural products with target-specific binding ability and good biological activity. Therefore, natural products have become an important source for drug discovery of major disease treatments. Whenever a new game-changing drug emerges, it is usually, though not every time, accompanied by the discovery of a new type of natural product, which also promotes the development of medicinal chemistry and life sciences.

TargetMol's Natural Product Library for HTS has a collection of 4617 carefully selected natural product monomers. These natural product monomers are widely sourced, structurally diversed and highly representative. They exist in natural sources extracted and purified from more than 2,900 kinds of Chinese medicinal herbs, animals and microorganisms, covering more than 500 different scaffolds and more than 1,000 target receptors, and most of the components have reached the purity of reference standards. In addtion, the library also contains many rare natural products with extremely high unit prices, which makes the library highly cost-effective. TargetMol's Natural Product Library for HTS is a powerful tool for drug development, pharmacological research, stem cell differentiation, fingerprint research, quality research and other fields.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L6000

Natural Product Library for HTS

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 4617 pure natural products and their derivatives with known biological activity for drug discovery, pharmacological study, stem cell differentiation, fingerprint study and quality research, and can be used for high throughput screening (HTS) and high content screening (HCS);
  • Documentation with clear source: isolated natural products from plant, animal, microorganism, etc.
  • Structurally diverse: 4617 natural products, including diverse types of structures, such as alkaloids, limonoids, sequiterpenes, diterpenes, pentacyclic triterpenes, sterols, and many other representatives which provide the structural diversity inherent in this group;
  • Detailed compound information with structure, solubility, target, activity, IC50 value, and biological activity description;
  • Cost-effective and competitive price to save your fundings.

Advantages Introduction Advantages Introduction

High Standards for Entry Criteria

In high-throughput screening (HTS), the quality of the compound library directly determines the accuracy and reliability of the screening results. TargetMol’s Natural Product Library has established extremely high entry standards to ensure that every compound in the library is a structurally defined and high-purity monomer compound. We not only exclude compounds with ambiguous structures, such as mixtures and polymers llike Casanthranol and Heparan Sulfate, but also ensure structural accuracy and high purity of each monomer compound through stringent quality control processes.

Remarkable Structural Diversity

TargetMol’s Natural Product Library features rich scaffold diversity and structural complexity, including multiple chiral centers and higher molecular rigidity, showcasing significant advantages in new drug discovery. TargetMol’s Natural Product Library can be classified into 2,624 categories based on MACCS molecular fingerprints. Its abundant chemical structural diversity provides a solid foundation for identifying novel lead compounds, greatly promoting pharmaceutical innovation.

 Natural Product Library for HTS
Library Diversity Analysis

Superior Potential for Proprietary Drugs

65% of natural products in TargetMol’s Natural Product Library comply with Lipinski's "Rule of Five" (Ro5), as exemplified by RO5 Drug-like Natural Product Library (L6160), indicating that TargetMol's natural products possess excellent bioavailability and permeability.

 Natural Product Library for HTS  Natural Product Library for HTS
 Natural Product Library for HTS  Natural Product Library for HTS
 Natural Product Library for HTS  Natural Product Library for HTS
Analysis on Drug-like Parameter

Multidimensional Pharmacokinetic Analysis

A multi-dimensional evaluation was conducted on TargetMol’s Natural Product Library, covering key pharmacological parameters such as blood-brain barrier penetration, cardiotoxicity (hERG K+ channel blocking), plasma protein binding rate, intestinal absorption, oral and dermal absorption performance, among others.

 Natural Product Library for HTS  Natural Product Library for HTS  Natural Product Library for HTS

• 13% of compounds can cross the blood-brain barrier, while 87% cannot. • 77% of compounds exhibit cardiotoxicity, while 23% do not. • 88% of compounds show a plasma protein binding within a reasonable range, while 12% fall outside the reasonable range.

 Natural Product Library for HTS  Natural Product Library for HTS  Natural Product Library for HTS

• 36% of compounds are highly absorbable in the small intestine, 38% are absorbable in the small intestine, and 26% are poorly absorbable in the small intestine. • 44% of compounds are highly orally absorbable, 38% are orally absorbable, and 18% are poorly orally absorbable. • 88% of compounds are absorbable through the skin, while 12% are poorly absorbable through the skin.

Packaging And Storage | TargetMol Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

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Endogenous Metabolite
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MT Receptor
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