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TargetMol | Compound Library

Cytokine Inhibitor Library

Catalog No. L3600

Cytokines are a broad and loose category of small proteins (~5–20 kDa) that are important in cell signaling, modulate the balance between humoral and cell-based immune responses, and are heavily involved in autoimmune and inflammatory diseases. Blocking cytokine signaling pathways by biologics has shown clinical effectiveness in these diseases. Cytokines act through receptors and activate related signaling to modulate gene expression and cell functions. Cytokine receptors activate many signaling pathways: JAK-STAT, NF-kB, MAPK, PI3K, etc. A number of small molecular weight inhibitors targeting cytokine signaling have been identified as research progresses and some are approved to be marketed. Cytokines Inhibitors Library from TargetMol, containing 815 compounds targeting cytokine signaling, can be used for high throughput and high content screening for drug discovery.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L3600

Cytokine Inhibitor Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 815 compounds targeting cytokine signaling for high throughput screening and high content screening for drug discovery;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials, and most of them are approved to be marketed;
  • Targets cover various cytokines including IL, CSF, IFN, TNF, TGF-beta family, growth factors, chemokine family, etc;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

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Library Customization | TargetMol Library Composition

EGFR
VEGFR
TNF
IL Receptor
PDGFR
FGFR
Apoptosis
Autophagy
c-Kit
CCR
TGF-beta/Smad
FLT
CXCR
IGF-1R
Src
NF-κB
Interleukin
c-Fms
c-Met/HGFR
ALK
COX
Bcr-Abl
HER
JAK
c-RET
Raf
Endogenous Metabolite
HIV Protease
Antibacterial
Potassium Channel
p38 MAPK
CSF-1R
CDK
Aurora Kinase
ERK
Akt
Tyrosine Kinases
STAT
NO Synthase
IFNAR
PI3K
JNK
Caspase
PDE
TAM Receptor
FAK
Drug Metabolite
TLR
Trk receptor
IκB/IKK
MEK
Antioxidant
PKC
Reactive Oxygen Species
mTOR
5-HT Receptor
Tyrosinase
NOS
Ferroptosis
PKA
PPAR
Parasite
MAPK
NOD
S6 Kinase
MLK
Mitophagy
GSK-3
Calcium Channel
Molecular Glues
MMP
Chk
Cytochromes P450
Ephrin Receptor
Bcl-2 Family
Influenza Virus
Ligand for E3 Ligase
HDAC
AMPK
Syk
Antibiotic
NOD-like Receptor (NLR)
HCV Protease
Antifungal
Tie-2
Virus Protease
PYK2
Immunology/Inflammation related
Mitochondrial Metabolism
BTK
Cholinesterase (ChE)
DNA/RNA Synthesis
P-gp
Antiviral
STING
SARS-CoV
Beta Amyloid
Sodium Channel
HIF/HIF Prolyl-Hydroxylase
IKZF
Chloride channel
Integrin
MyD88
Dehydrogenase
HBV
Wnt/beta-catenin
PARP
Adrenergic Receptor
Glucocorticoid Receptor
IRE1
RIP kinase
LDL
ROS
Prostaglandin Receptor
Sirtuin
transporter
Nrf2
Casein Kinase
PDK
GABA Receptor
PLK
Discoidin Domain Receptor (DDR)
Anti-infection
p53
FOXO3
GPCR
Proteasome
ROR
DNA-PK
LTR
Adenosine Receptor
Arrestin
NADPH
Lipase
Histamine Receptor
gp120/CD4
Glutathione Peroxidase
Phosphatase
GTPase
VDA
Progesterone Receptor
c-Myc
MRP
Serine Protease
Hck
Serine/threonin kinase
Cell Cycle Arrest
Leukotriene Receptor
NAMPT
Glucokinase
TRP/TRPV Channel
ROCK
Amylase
MAO
iGluR
Topoisomerase
Annexin A
E1/E2/E3 Enzyme
Antifection
Fatty Acid Synthase
DNA Alkylation
FAAH
ACK1
PTEN
PAD
cAMP
GluR
Epigenetic Reader Domain
Lipoxygenase
CaMK
PGE Synthase
MNK
LRRK2
Free radical scavengers
AIM2
Histone Acetyltransferase
PAI-1
Pyroptosis
RSV
Hippo pathway
Reverse Transcriptase
Phospholipase
HIF
SGK
Complement System
Gap Junction Protein
NADPH-oxidase
IRAK
Microtubule Associated
ROS Kinase
CFTR
PKM
ADC Cytotoxin

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