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MSC-4381

Name: MSC-4381
Brand: TargetMol
SKU: T37824
Price: 64 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T37824Cas No. 2445185-57-7

Alias MSC4381, MSC 4381, MCT4-IN-1

MSC-4381 (MCT4-IN-1) is an orally available and selectively modeled highly potent inhibitor of monocarboxylic acid transporter protein 4 (MCT4/SLC16A3) with potential anticancer and antitumor activity for the study of osteosarcoma.

MSC-4381

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Purity: 99.04%

Catalog No. T37824Alias MSC4381, MSC 4381, MCT4-IN-1Cas No. 2445185-57-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$64	-	In Stock
5 mg	$156	-	In Stock
10 mg	$239	-	In Stock
25 mg	$413	-	In Stock
50 mg	$579	7-10 days	7-10 days
100 mg	$828	7-10 days	7-10 days
200 mg	$1,090	7-10 days	7-10 days
1 mL x 10 mM (in DMSO)	$185	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.04%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	MSC-4381 (MCT4-IN-1) is an orally available and selectively modeled highly potent inhibitor of monocarboxylic acid transporter protein 4 (MCT4/SLC16A3) with potential anticancer and antitumor activity for the study of osteosarcoma.
In vitro	MCT4-IN-1 (compound 18n) inhibits lactate efflux in the MDA-MB-231 cell line with an IC50 of 1 nM. On-target activity was confirmed by fluorescence cross correlation spectroscopy (FCCS)[1] with a Ki of 11 nM[1].
In vivo	When MCT4-IN-1 (30 mg/kg; oral; single dose) was used only in combination with MCT1/2 inhibitors, lactic acid accumulation in tumor cells was significant; MCT4-IN-1 (30 mg/kg/day; for 15 consecutive days) had no significant antitumor activity; MCT4-IN-1 (0.2 mg/kg; intravenous injection) had a T1/2 of 1 hour, a CL of 0.33 L/hkg, a Cmax of 489 ng/mL, and a Vss of 0.4 L/kg in mice[1].
Synonyms	MSC4381, MSC 4381, MCT4-IN-1

Chemical Properties

Molecular Weight	537.97
Formula	C₂₆H₂₀ClN₃O₆S
Cas No.	2445185-57-7
Smiles	CCOc1ccc(c2ncccc12)S(=O)(=O)Nc1ccc(Cl)cc1C#Cc1cnc(cc1OC)C(O)=O
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (92.94 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (4.65 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8588 mL	9.2942 mL	18.5884 mL	92.9420 mL
5 mM	0.3718 mL	1.8588 mL	3.7177 mL	18.5884 mL
10 mM	0.1859 mL	0.9294 mL	1.8588 mL	9.2942 mL
20 mM	0.0929 mL	0.4647 mL	0.9294 mL	4.6471 mL
50 mM	0.0372 mL	0.1859 mL	0.3718 mL	1.8588 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc