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Telisotuzumab(ABT-700) is a humanized recombinant antibody targeting the therapeutic hepatocyte growth factor receptor (MET) with high affinity for c-Met.Telisotuzumab has inhibitory effects on c-Met signaling and antitumor activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 372.00 | |
5 mg | In stock | $ 933.00 | |
10 mg | In stock | $ 1,490.00 | |
25 mg | In stock | $ 2,190.00 | |
50 mg | In stock | $ 2,970.00 | |
100 mg | In stock | $ 3,930.00 |
Description | Telisotuzumab(ABT-700) is a humanized recombinant antibody targeting the therapeutic hepatocyte growth factor receptor (MET) with high affinity for c-Met.Telisotuzumab has inhibitory effects on c-Met signaling and antitumor activity. |
In vitro | Telisotuzumab (ABT-700) (10 μg/mL; 24 h) can inhibit the proliferation of SNU5 cells and lead to an increase in pro-apoptotic Bim and a decrease in anti-apoptotic Bcl-xL, thereby inducing apoptosis.[1] |
In vivo | Telisotuzumab (ABT-700) (2.5-40 mg/kg; i.p.; twice a week; 90 days) potently antagonizes constitutively activated c-Met and downstream signaling, thereby inhibiting tumor growth in Hs746T cell-derived SCID mice.[1] |
Synonyms | ABT-700, Mab-224G11 |
Molecular Weight | N/A |
CAS No. | 1781223-80-0 |
store at low temperature
store at -20°C
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Telisotuzumab 1781223-80-0 Tyrosine Kinase/Adaptors c-Met/HGFR ABT-700 Mab-224G11 ABT 700 ABT700 inhibitor inhibit