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Telisotuzumab (Alias: Mab-224G11, ABT-700)
Catalog No. T77437 Copy Product Info
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Telisotuzumab(ABT-700) is a humanized recombinant antibody targeting the therapeutic hepatocyte growth factor receptor (MET) with high affinity for c-Met.Telisotuzumab has inhibitory effects on c-Met signaling and antitumor activity.
Telisotuzumab
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Catalog No. T77437
Alias Mab-224G11, ABT-700
Telisotuzumab(ABT-700) is a humanized recombinant antibody targeting the therapeutic hepatocyte growth factor receptor (MET) with high affinity for c-Met.Telisotuzumab has inhibitory effects on c-Met signaling and antitumor activity.
Cas No. 1781223-80-0
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $372 | - | In Stock | |
| 5 mg | $933 | Inquiry | Inquiry | |
| 10 mg | $1,490 | Inquiry | Inquiry | |
| 25 mg | $2,190 | Inquiry | Inquiry | |
| 50 mg | $2,970 | Inquiry | Inquiry | |
| 100 mg | $3,930 | Inquiry | Inquiry |
In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:96.1% (SDS-PAGE); 98.5% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | Telisotuzumab(ABT-700) is a humanized recombinant antibody targeting the therapeutic hepatocyte growth factor receptor (MET) with high affinity for c-Met.Telisotuzumab has inhibitory effects on c-Met signaling and antitumor activity. |
| In vitro | Telisotuzumab (ABT-700) (10 μg/mL; 24 h) inhibits SNU5 cell proliferation, increases pro-apoptotic Bim, decreases anti-apoptotic Bcl-xL, and induces apoptosis.[1] |
| In vivo | Telisotuzumab (ABT-700) (2.5-40 mg/kg; i.p.; twice a week; 90 days) potently antagonizes constitutively activated c-Met and downstream signaling, thereby inhibiting tumor growth in Hs746T cell-derived SCID mice.[1] |
| Synonyms | Mab-224G11, ABT-700 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | HGFR/c-Met |
| Molecular Weight | 145.50 kDa |
| Cas No. | 1781223-80-0 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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