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Telisotuzumab (Synonyms: Mab-224G11, ABT-700)
Catalog No. T77437 Copy Product Info
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Telisotuzumab(ABT-700) is a humanized recombinant antibody targeting the therapeutic hepatocyte growth factor receptor (MET) with high affinity for c-Met.Telisotuzumab has inhibitory effects on c-Met signaling and antitumor activity.
Telisotuzumab
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Catalog No. T77437
Synonyms Mab-224G11, ABT-700
Telisotuzumab(ABT-700) is a humanized recombinant antibody targeting the therapeutic hepatocyte growth factor receptor (MET) with high affinity for c-Met.Telisotuzumab has inhibitory effects on c-Met signaling and antitumor activity.
Cas No. 1781223-80-0
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $372 | - | In Stock | |
| 5 mg | $933 | Inquiry | Inquiry | |
| 10 mg | $1,490 | Inquiry | Inquiry | |
| 25 mg | $2,190 | Inquiry | Inquiry | |
| 50 mg | $2,970 | Inquiry | Inquiry | |
| 100 mg | $3,930 | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:96.1% (SDS-PAGE); 98.5% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | Telisotuzumab(ABT-700) is a humanized recombinant antibody targeting the therapeutic hepatocyte growth factor receptor (MET) with high affinity for c-Met.Telisotuzumab has inhibitory effects on c-Met signaling and antitumor activity. |
| In vitro | Telisotuzumab (ABT-700) (10 μg/mL; 24 h) inhibits SNU5 cell proliferation, increases pro-apoptotic Bim, decreases anti-apoptotic Bcl-xL, and induces apoptosis.[1] |
| In vivo | Telisotuzumab (ABT-700) (2.5-40 mg/kg; i.p.; twice a week; 90 days) potently antagonizes constitutively activated c-Met and downstream signaling, thereby inhibiting tumor growth in Hs746T cell-derived SCID mice.[1] |
| Synonyms | Mab-224G11, ABT-700 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | HGFR/c-Met |
| Molecular Weight | 145.50 kDa |
| Cas No. | 1781223-80-0 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
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