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Losartan Carboxylic Acid

Name: Losartan Carboxylic Acid
Brand: TargetMol
SKU: T3461
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T3461Cas No. 124750-92-1

Alias EXP-3174, E-3174

Losartan Carboxylic Acid (E-3174), a potent AT1 antagonist (Kis: 0.57 nM, rat; 0.67 nM, human), produces a depressor response and vasodilatation. As a metabolite of losartan, it is more potent than losartan in blocking angiotensin II-induced responses in vascular smooth muscle cells.

Losartan Carboxylic Acid

🥰Excellent

Purity: 99.28%

Catalog No. T3461Alias EXP-3174, E-3174Cas No. 124750-92-1

Pack Size	Price	Availability
10 mg	$43	In Stock
25 mg	$88	In Stock
50 mg	$158	In Stock
100 mg	$236	In Stock
200 mg	$346	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Purity:99.28%

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Product Introduction

Bioactivity

Description	Losartan Carboxylic Acid (E-3174), a potent AT1 antagonist (Kis: 0.57 nM, rat; 0.67 nM, human), produces a depressor response and vasodilatation. As a metabolite of losartan, it is more potent than losartan in blocking angiotensin II-induced responses in vascular smooth muscle cells.
Synonyms	EXP-3174, E-3174

Chemical Properties

Molecular Weight	436.89
Formula	C₂₂H₂₁ClN₆O₂
Cas No.	124750-92-1
Smiles	C(N1C(CCCC)=NC(Cl)=C1C(O)=O)C2=CC=C(C=C2)C3=C(C=CC=C3)C=4NN=NN4
Relative Density.	1.41 g/cm3 (Predicted)
Color	White
Appearance	solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 70 mg/mL (160.22 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2889 mL	11.4445 mL	22.8891 mL	114.4453 mL
5 mM	0.4578 mL	2.2889 mL	4.5778 mL	22.8891 mL
10 mM	0.2289 mL	1.1445 mL	2.2889 mL	11.4445 mL
20 mM	0.1144 mL	0.5722 mL	1.1445 mL	5.7223 mL
50 mM	0.0458 mL	0.2289 mL	0.4578 mL	2.2889 mL
100 mM	0.0229 mL	0.1144 mL	0.2289 mL	1.1445 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc