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Anti-TREM-1 Antibody (8K185)

😃Good
Catalog No. TMAY-00920
Alias triggering receptor expressed on myeloid cells 1

Anti-TREM-1 Antibody (8K185) is a Mouse antibody targeting TREM-1. Anti-TREM-1 Antibody (8K185) can be used in FCM.

Anti-TREM-1 Antibody (8K185)

Anti-TREM-1 Antibody (8K185)

😃Good
Catalog No. TMAY-00920Alias triggering receptor expressed on myeloid cells 1
Anti-TREM-1 Antibody (8K185) is a Mouse antibody targeting TREM-1. Anti-TREM-1 Antibody (8K185) can be used in FCM.
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100 μL$199 7-10 days
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Product Introduction

Bioactivity
Description
Anti-TREM-1 Antibody (8K185) is a Mouse antibody targeting TREM-1. Anti-TREM-1 Antibody (8K185) can be used in FCM.
Aliastriggering receptor expressed on myeloid cells 1
Ig Type
Monoclonal Mouse IgG1
Clone
8K185
Reactivity
Human
Verified Activity
Flow cytometric analysis of Human TREM-1(CD354) expression on human whole blood granulocytes. Cells were stained with purified anti-Human TREM-1(CD354), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Application
FCM
Recommended Dose
FCM: 1:25-1:100
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionThis antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human TREM-1 / TREM1 (rh TREM-1 / TREM1; TMPY-00943; NP_061113.1; Met1-Arg200). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundTREM1 (triggering receptor expressed on myeloid cells) is a type I transmembrane protein with a single Ig-like domain, and is selectively expressed on blood neutrophils and a subset of monocytes. As a member of the growing family of receptors related to NK cell receptors, TREM1 activates downstream signaling events with the help of an adapter protein called DAP12. Expression of TREM1 is up-regulated by bacterial LPS, a ligand for TLR4, as well as lipoteichoic acid. Although its natural ligand has not been identified, engagement of TREM1 with agonist mAbs triggers secretion of the proinflammatory cytokines TNF-α and IL-1β, as well as chemokines such as IL-8 and monocyte chemoattractant protein (MCP)-1. Intracellularly, TREM1 induces Ca2+ mobilization and tyrosine phosphorylation of extracellular signal-related kinase 1 (ERK1), ERK2 and phospholipase C-γ. In an animal model of LPS-induced septic shock, blockade of TREM1 signaling inhibited hyperresponsiveness and death. Thus, it has been demonstrated that TREM1 performs a critical function in immune responses involved in host defense against microbial challenges, and is suggested to be a potential therapeutic target for septic shock.
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
PE
Antibody Types Available
2
Antigen Details
Immunogen
Recombinant Human TREM-1 / TREM1 Protein (TMPY-00943)
Antigen Species
Human
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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