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Magnesium isoglycyrrhizinate hydrate

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Catalog No. TN7831Cas No. 658701-67-8
Alias Tianqingganmei, 18α-Glycyrrhizic acid Magnesium hydrate

Magnesium isoglycyrrhizinate hydrate (18α-Glycyrrhizic acid Magnesium hydrate) is an active ingredient derived from licorice with anti-inflammatory properties. It lowers alanine and aspartate aminotransferase activities and can be used in HIV-1 infection research.

Magnesium isoglycyrrhizinate hydrate

Magnesium isoglycyrrhizinate hydrate

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Purity: 99.09%
Catalog No. TN7831Alias Tianqingganmei, 18α-Glycyrrhizic acid Magnesium hydrateCas No. 658701-67-8
Magnesium isoglycyrrhizinate hydrate (18α-Glycyrrhizic acid Magnesium hydrate) is an active ingredient derived from licorice with anti-inflammatory properties. It lowers alanine and aspartate aminotransferase activities and can be used in HIV-1 infection research.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$38-In Stock
5 mg$60-In Stock
10 mg$87-In Stock
25 mg$145-In Stock
50 mg$213-In Stock
100 mg$318-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.09%
Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
Magnesium isoglycyrrhizinate hydrate (18α-Glycyrrhizic acid Magnesium hydrate) is an active ingredient derived from licorice with anti-inflammatory properties. It lowers alanine and aspartate aminotransferase activities and can be used in HIV-1 infection research.
In vivo
Magnesium isoglycyrrhizinate hydrate (15 or 45 mg/kg.d, i.p., 18 days) was effective in inhibiting ethanol-induced spermatogenic epithelial tissue division and degeneration of supporting cells and germ cells, and was protective against oxidative damage of testis. [1]
Magnesium isoglycyrrhizinate hydrate (0.40 or 0.80 mg/kg/d) exerts anti-inflammatory activity through the NLRP3 inflammatome pathway and improves chronic obstructive pulmonary disease in rats ina rat model. [2]
SynonymsTianqingganmei, 18α-Glycyrrhizic acid Magnesium hydrate
Chemical Properties
Molecular Weight917.28
FormulaC42H68MgO20
Cas No.658701-67-8
SmilesC[C@]12[C@@](C(C=C3[C@]2(CC[C@@]4([C@]3([H])C[C@](C)(CC4)C(O)=O)C)C)=O)([H])[C@@]5([C@@](C(C)([C@H](CC5)O[C@@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C([O-])=O)O)O)O[C@@H]7O[C@@H]([C@H]([C@@H]([C@H]7O)O)O)C([O-])=O)C)([H])CC1)C.[Mg+2].O.O.O.O
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 20 mg/mL (21.8 mM), when pH is adjusted to 9 with NH3·H2O.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM1.0902 mL5.4509 mL10.9018 mL54.5090 mL
5 mM0.2180 mL1.0902 mL2.1804 mL10.9018 mL
10 mM0.1090 mL0.5451 mL1.0902 mL5.4509 mL
20 mM0.0545 mL0.2725 mL0.5451 mL2.7254 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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