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PARP-1-IN-1

Catalog No. T61798

PARP-1-IN-1 is a highly selective and orally active inhibitor of the enzyme PARP-1, with an IC50 value of 0.96 nM. It exhibits excellent tolerance and demonstrates significant activity in a single dose in the MDA-MB-436 xenotransplantation model [1].

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

PARP-1-IN-1, CAS N/A

Pack Size	Availability	Price/USD
25 mg	10-14 weeks	$ 1,520.00
50 mg	10-14 weeks	$ 1,980.00
100 mg	10-14 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	PARP-1-IN-1 is a highly selective and orally active inhibitor of the enzyme PARP-1, with an IC50 value of 0.96 nM. It exhibits excellent tolerance and demonstrates significant activity in a single dose in the MDA-MB-436 xenotransplantation model [1].
In vitro	PARP-1-IN-1 (compound Y49), over a 48-hour period, demonstrates effective inhibition of various cancer cells, with IC50 values of 9.64, 123.5, and 106.3 μM for MX-1, MCF7, and A548 cells, respectively. At concentrations ranging from 2.5 to 10 μM, it notably inhibits PARP-1 activity and decreases PAR production in A549 cells, exhibiting dose-dependent efficacy [1]. Western Blot Analysis confirms that PARP-1-IN-1, at 2.5 μM, 5 μM, and 10 μM concentrations and following a 48-hour incubation, successfully suppresses PARP-1 activity and lowers PAR levels in cancer cells, demonstrating its dose-dependent nature [1].
In vivo	PARP-1-IN-1 (Compound Y49) administered orally at a dosage of 50 mg/kg/day for 18 days significantly inhibits the growth of MDA-MB-436 tumors in female athymic BALB/c nude mice without causing a significant change in the body weight of the treated mice. This finding highlights the compound's potential as a targeted therapy for this tumor model.

Molecular Weight	392.47
Formula	C23H25FN4O

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
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The answer of 19.713 mg appears in the Mass box

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The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PARP-1-IN-1 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.