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EB-47

Name: EB-47
Brand: TargetMol
SKU: T11143
Price: 62 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11143 Copy Product Info

Purity: 99.81%

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EB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite.EB-47, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM, shows modest potency against ARTD5 with an IC50 value of 410 nM.

Cas No. 366454-36-6

Pack Size	Price	USA Stock	Global Stock
1 mg	$62	In Stock	In Stock
5 mg	$133	In Stock	In Stock
10 mg	$223	In Stock	In Stock
25 mg	$397	In Stock	In Stock
50 mg	$733	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$179	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.81%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	EB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite.EB-47, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM, shows modest potency against ARTD5 with an IC50 value of 410 nM.
Targets & IC50	ARTD1/PARP1:45 nM
In vitro	The inhibitory effect of EB-47 on CdPARP and HsPARP was 0.86 and 1.0uM with IC50 value respectively, and the inhibitory effect on CdPARP was over 50%[1].
In vivo	EB-47, at a concentration of 2 μM for a duration of 5 days, reduces the number of embryo implantation sites and the quantity of blastocysts observed on day 5. PARP1 is involved in the embryo implantation process[1].

Chemical Properties

Molecular Weight	537.53
Formula	C₂₄H₂₇N₉O₆
Cas No.	366454-36-6
Smiles	O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](C(=O)N4CCN(CC(NC5=C6C(C(=O)NC6)=CC=C5)=O)CC4)[C@H]1O
Relative Density.	1.83 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 22.5 mg/mL (41.86 mM), Sonication is recommended.

H2O: 100 mg/mL (186.04 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 2.25 mg/mL (4.19 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.8604 mL	9.3018 mL	18.6036 mL	93.0181 mL
5 mM	0.3721 mL	1.8604 mL	3.7207 mL	18.6036 mL
10 mM	0.1860 mL	0.9302 mL	1.8604 mL	9.3018 mL
20 mM	0.0930 mL	0.4651 mL	0.9302 mL	4.6509 mL

H2O

	1mg	5mg	10mg	50mg
50 mM	0.0372 mL	0.1860 mL	0.3721 mL	1.8604 mL
100 mM	0.0186 mL	0.0930 mL	0.1860 mL	0.9302 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc