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CD47 Protein, Human, Recombinant (His)

Catalog No. TMPJ-00211
Synonyms: MER6, Integrin-Associated Protein, Leukocyte Surface Antigen CD47, Protein MER6, CD47, Antigenic Surface Determinant Protein OA3, IAP

CD47(Integrin-Associated Protein,IAP) is a 40 ‑ 60 kDa variably glycosylated atypical member of the immunoglobulin superfamily. The ubiquitously expressed CD47 binds to SIRP family members on macrophages, neutrophils, and T cells. CD47 is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The protein is also a receptor for the C-terminal cell-binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This protein has broad tissue distribution, and is reduced in expression on Rh erythrocytes.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
CD47 Protein, Human, Recombinant (His)
Pack Size Availability Price/USD Quantity
10 μg In stock $ 63.00
50 μg 5 days $ 175.00
500 μg 5 days $ 1,220.00
1 mg 5 days $ 2,730.00
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Biological Description
Technical Params
Product Properties
Biological Information Loaded Anti-Human CD47 mAb-Fc on Protein A Biosensor, can bind Human CD47-His with an affinity constant of 0.22 nM as determined in BLI assay. (Regularly tested)

Description CD47(Integrin-Associated Protein,IAP) is a 40 ‑ 60 kDa variably glycosylated atypical member of the immunoglobulin superfamily. The ubiquitously expressed CD47 binds to SIRP family members on macrophages, neutrophils, and T cells. CD47 is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The protein is also a receptor for the C-terminal cell-binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This protein has broad tissue distribution, and is reduced in expression on Rh erythrocytes.
Species Human
Expression System Human Cells
Tag C-6His
Accession Number Q08722
Synonyms MER6, Integrin-Associated Protein, Leukocyte Surface Antigen CD47, Protein MER6, CD47, Antigenic Surface Determinant Protein OA3, IAP
Amino Acid Gln19-Pro139
Construction Recombinant Human Leukocyte Surface Antigen CD47 is produced by our Mammalian expression system and the target gene encoding Gln19-Pro139 is expressed with a 6His tag at the C-terminus.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)

Molecular Weight 30-45 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Lyophilized from a 0.2 μm filtered solution of 10mM Tris-Citrate, 150mM NaCl, pH 8.0.
Reconstitution Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Stability & Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Research Background CD47(Integrin-Associated Protein,IAP) is a 40 ‑ 60 kDa variably glycosylated atypical member of the immunoglobulin superfamily. The ubiquitously expressed CD47 binds to SIRP family members on macrophages, neutrophils, and T cells. CD47 is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The protein is also a receptor for the C-terminal cell-binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This protein has broad tissue distribution, and is reduced in expression on Rh erythrocytes.

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Keywords

CD47 Protein, Human, Recombinant (His) MER6 Integrin-Associated Protein Leukocyte Surface Antigen CD47 CD 47 CD-47 Protein MER6 MER-6 CD47 Antigenic Surface Determinant Protein OA3 IAP MER 6 recombinant recombinant-proteins proteins protein

 

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