PD 123319 ditrifluoroacetate is a selective, non-peptide angiotensin II type 2 (AT2) receptor antagonist, and PD 123319 ditrifluoroacetate demonstrates potent activity with IC50 values of 34 nM in rat adrenal tissue and 210 nM in rat brain, thereby providing a valuable pharmacological tool for elucidating AT2 receptor function in cardiovascular and renal physiology and supporting research in hypertension and related disorders.

AT2 receptor:34 nM

PD 123319 ditrifluoroacetate can effectively distinguish between the two subtypes of angiotensin II (AII) receptors. In experiments with bovine adrenal cell membranes, 125I-AII labeled these two binding sites: approximately 85% were DuP-753-sensitive, exhibiting high affinity for DuP-753 (IC50 of 92.9 nM) and unaffected by PD 123319 ditrifluoroacetate; the remaining sites were highly sensitive to PD 123319 ditrifluoroacetate (IC50 of 6.9 nM) but showed very low affinity for DuP-753 (IC50 around 10 µM). [1]