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Anti-Phospho-TBC1D4 (Ser588) Polyclonal Antibody
Catalog No. TMAB-11364 Copy Product Info
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Anti-Phospho-TBC1D4 (Ser588) Polyclonal Antibody is a Rabbit antibody targeting Phospho-TBC1D4 (Ser588). Anti-Phospho-TBC1D4 (Ser588) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-Phospho-TBC1D4 (Ser588) Polyclonal Antibody
Copy Product Info🥰Excellent
Catalog No. TMAB-11364
Anti-Phospho-TBC1D4 (Ser588) Polyclonal Antibody is a Rabbit antibody targeting Phospho-TBC1D4 (Ser588). Anti-Phospho-TBC1D4 (Ser588) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-Phospho-TBC1D4
(Ser588) Polyclonal Antibody
(Ser588) Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
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| Description | Anti-Phospho-TBC1D4 (Ser588) Polyclonal Antibody is a Rabbit antibody targeting Phospho-TBC1D4 (Ser588). Anti-Phospho-TBC1D4 (Ser588) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Rat (predicted:Human,Cow,Rabbit) |
| Verified Activity | Paraformaldehyde-fixed, paraffin embedded (rat brain tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (TBC1D4 (Ser588)) Polyclonal Antibody, Unconjugated (TMAB-11364) at 1:400 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructions and DAB staining. |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Isoform 2 shows a cytoplasmic perinuclear localization in a myoblastic cell line in resting and insulin-stimulated cells. |
| Tissue Specificity | Widely expressed. Isoform 2 is the highest overexpressed in most tissues. Isoform 1 is highly expressed in skeletal muscle and heart, but was not detectable in the liver nor in adipose tissue. Isoform 2 is strongly expressed in adrenal and thyroid gland, and also in lung, kidney, colon, brain and adipose tissue. Isoform 2 is moderately expressed in skeletal muscle. Expressed in pancreatic Langerhans islets, including beta cells (at protein level). Expression is decreased by twofold in pancreatic islets in type 2 diabetes patients compared to control subjects. Up-regulated in T-cells from patients with atopic dermatitis. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. |
| Immunogen | KLH conjugated synthesised phosphopeptide: human TBC1D4 around the phosphorylation site of Ser588 |
| Antigen Species | Human |
| Gene Name | TBC1D4 |
| Gene ID | |
| Protein Name | TBC1 domain family member 4 |
| Uniprot ID | |
| Function | May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. |
| Molecular Weight | Theoretical: 60/147 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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