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116-9e

Name: 116-9e
Brand: TargetMol
SKU: T25770
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T25770Cas No. 831217-43-7

Alias MAL2-11B, MAL-2-11B, MAL211B, MAL2 11B, MAL 2 11B

116-9e (MAL2-11B) is a potent Hsp70 co-chaperone DNAJA1 inhibitor with antiviral properties, inhibiting simian virus 40 (SV40) replication, tumour antigen (TAg) endogenous ATPase activity, and TAg-mediated activation of Hsp70. 116-9e can be used to study cancer drug resistance.

116-9e

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Purity: 99.55%

Catalog No. T25770Alias MAL2-11B, MAL-2-11B, MAL211B, MAL2 11B, MAL 2 11BCas No. 831217-43-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	In Stock	In Stock
5 mg	$113	In Stock	In Stock
10 mg	$188	In Stock	In Stock
25 mg	$395	In Stock	In Stock
50 mg	$662	In Stock	In Stock
100 mg	$957	In Stock	In Stock
200 mg	$1,280	-	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.55%

Appearance:Solid

Color:Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	116-9e (MAL2-11B) is a potent Hsp70 co-chaperone DNAJA1 inhibitor with antiviral properties, inhibiting simian virus 40 (SV40) replication, tumour antigen (TAg) endogenous ATPase activity, and TAg-mediated activation of Hsp70. 116-9e can be used to study cancer drug resistance.
In vitro	116-9e (MAL2-11B) inhibits Hsp70 stimulated by TAg more effectively than MAL3-101, significantly reducing virus replication and DNA synthesis. MAL2-11B also inhibits the activity of the TAg ATPase domain[1].116-9e (MAL2-11B; 15 μM; 5 days) significantly decreases BK virus in human renal cell lines[2].
Synonyms	MAL2-11B, MAL-2-11B, MAL211B, MAL2 11B, MAL 2 11B

Chemical Properties

Molecular Weight	512.6
Formula	C₃₁H₃₂N₂O₅
Cas No.	831217-43-7
Smiles	C(OCC1=CC=CC=C1)(=O)C=2C(NC(=O)N(CCCCCC(O)=O)C2C)C3=CC=C(C=C3)C4=CC=CC=C4
Relative Density.	1.205 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (156.07 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.44 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9508 mL	9.7542 mL	19.5084 mL	97.5419 mL
5 mM	0.3902 mL	1.9508 mL	3.9017 mL	19.5084 mL
10 mM	0.1951 mL	0.9754 mL	1.9508 mL	9.7542 mL
20 mM	0.0975 mL	0.4877 mL	0.9754 mL	4.8771 mL
50 mM	0.0390 mL	0.1951 mL	0.3902 mL	1.9508 mL
100 mM	0.0195 mL	0.0975 mL	0.1951 mL	0.9754 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc