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116-9e

Catalog No. T25770   CAS 831217-43-7
Synonyms: MAL-2-11B, MAL2-11B, MAL211B, MAL 2 11B, MAL2 11B

116-9e (MAL2-11B) is a potent Hsp70 co-chaperone DNAJA1 inhibitor with antiviral properties, inhibition of simian virus 40 (SV40) replication, inhibition of tumour antigen (TAg) endogenous ATPase activity, and TAg-mediated activation of Hsp70.116-9e can be used to study cancer drug resistance.

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116-9e Chemical Structure
116-9e, CAS 831217-43-7
Pack Size Availability Price/USD Quantity
5 mg In stock $ 113.00
10 mg In stock $ 188.00
25 mg In stock $ 395.00
50 mg In stock $ 688.00
100 mg In stock $ 957.00
500 mg In stock $ 1,890.00
1 mL * 10 mM (in DMSO) In stock $ 30.00
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Purity: 99.55%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description 116-9e (MAL2-11B) is a potent Hsp70 co-chaperone DNAJA1 inhibitor with antiviral properties, inhibition of simian virus 40 (SV40) replication, inhibition of tumour antigen (TAg) endogenous ATPase activity, and TAg-mediated activation of Hsp70.116-9e can be used to study cancer drug resistance.
In vitro 116-9e (MAL2-11B) inhibits Hsp70 stimulated by TAg more effectively than MAL3-101, significantly reducing virus replication and DNA synthesis. MAL2-11B also inhibits the activity of the TAg ATPase domain[1].116-9e (MAL2-11B; 15 μM; 5 days) significantly decreases BK virus in human renal cell lines[2].
Synonyms MAL-2-11B, MAL2-11B, MAL211B, MAL 2 11B, MAL2 11B
Molecular Weight 512.6
Formula C31H32N2O5
CAS No. 831217-43-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 80 mg/mL (156.07 mM), Sonication is recommended.

TargetMolReferences and Literature

1. Nitika, et al. Chemogenomic screening identifies the Hsp70 co-chaperone DNAJA1 as a hub for anticancer drug resistance. Sci Rep. 2020 Aug 14;10(1):13831. 2. Christine M Wright, et al. Inhibition of Simian Virus 40 replication by targeting the molecular chaperone function and ATPase activity of T antigen. Virus Res. 2009 Apr;141(1):71-80.

Related compound libraries

This product is contained In the following compound libraries:
Inhibitor Library

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Keywords

116-9e 831217-43-7 Microbiology/Virology Virus Protease MAL-2-11B 116 9e MAL2-11B MAL211B MAL 2 11B MAL2 11B 1169e inhibitor inhibit

 

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