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SR9011

Name: SR9011
Brand: TargetMol
SKU: T3688
Price: 53 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3688Cas No. 1379686-29-9

SR9011 is a REV-ERB agonist (IC50: 790 nM, REV-ERBα; IC50: 560 nM, REV-ERBβ).

SR9011

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Purity: 99.65%

Catalog No. T3688Cas No. 1379686-29-9

SR9011 is a REV-ERB agonist (IC50: 790 nM, REV-ERBα; IC50: 560 nM, REV-ERBβ).

Pack Size	Price	Availability
1 mg	$53	In Stock
2 mg	$76	In Stock
5 mg	$155	In Stock
10 mg	$273	In Stock
25 mg	$465	In Stock
50 mg	$682	In Stock
1 mL x 10 mM (in DMSO)	$163	In Stock

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Purity:99.65%

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COA

Product Introduction

Bioactivity

Description	SR9011 is a REV-ERB agonist (IC50: 790 nM, REV-ERBα; IC50: 560 nM, REV-ERBβ).
Targets&IC50	Rev-Erb:790 nM, Rev-Erbα:560 nM
In vitro	SR9011 and SR9009 effectively inhibits transcription in a cotransfection assay using full-length REV-ERBα along with a luciferase reporter driven by the Bmal1 promoter (SR9011 IC50: 620 nM). SR9011 suppresses the expression of BMAL1 mRNA in HepG2 cells in a REV-ERBα/β-dependent manner.
In vivo	SR9011 inhibits the activity of the SCN clock, with reversible inhibition of circadian oscillations in SCN explants cultured from the Per2: Luc reporter mouse.

Chemical Properties

Molecular Weight	479.04
Formula	C₂₃H₃₁ClN₄O₃S
Cas No.	1379686-29-9
Smiles	CCCCCNC(=O)N1CCC(CN(Cc2ccc(s2)[N+]([O-])=O)Cc2ccc(Cl)cc2)C1
Relative Density.	1.254 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (104.38 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.18 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0875 mL	10.4375 mL	20.8751 mL	104.3754 mL
5 mM	0.4175 mL	2.0875 mL	4.1750 mL	20.8751 mL
10 mM	0.2088 mL	1.0438 mL	2.0875 mL	10.4375 mL
20 mM	0.1044 mL	0.5219 mL	1.0438 mL	5.2188 mL
50 mM	0.0418 mL	0.2088 mL	0.4175 mL	2.0875 mL
100 mM	0.0209 mL	0.1044 mL	0.2088 mL	1.0438 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc