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Desmopressin acetate (16679-58-6 free base)

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Catalog No. T5144Cas No. 62288-83-9
Alias Desmopressin acetate, DDAVP

Desmopressin acetate (16679-58-6 free base) (DDAVP) is the synthetic analog of the antidiuretic hormone arginine vasopressin. Vasopressin Receptor The antidiuretic properties of desmopressin have led to its use in polyuric conditions including primary nocturnal enuresis, nocturia, and diabetes insipidus. Desmopressin acetate (16679-58-6 free base) works by limiting the amount of water that is eliminated in the urine. Desmopressin acetate (16679-58-6 free base) binds to V2 receptors in renal collecting ducts, increasing water reabsorption. It also stimulates the release of von Willebrand factor from endothelial cells by acting on the V2 receptor.

Desmopressin acetate (16679-58-6 free base)
Other Forms of Desmopressin acetate (16679-58-6 free base):

Desmopressin acetate (16679-58-6 free base)

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Purity: 99.9%
Catalog No. T5144Alias Desmopressin acetate, DDAVPCas No. 62288-83-9
Desmopressin acetate (16679-58-6 free base) (DDAVP) is the synthetic analog of the antidiuretic hormone arginine vasopressin. Vasopressin Receptor The antidiuretic properties of desmopressin have led to its use in polyuric conditions including primary nocturnal enuresis, nocturia, and diabetes insipidus. Desmopressin acetate (16679-58-6 free base) works by limiting the amount of water that is eliminated in the urine. Desmopressin acetate (16679-58-6 free base) binds to V2 receptors in renal collecting ducts, increasing water reabsorption. It also stimulates the release of von Willebrand factor from endothelial cells by acting on the V2 receptor.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$45In StockIn Stock
2 mg$62In StockIn Stock
5 mg$98In StockIn Stock
10 mg$148In StockIn Stock
25 mg$252In StockIn Stock
50 mg$379In StockIn Stock
100 mg$567In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.9%
Appearance:Solid
Color:White
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COA MS HPLC

Product Introduction

Bioactivity
Description
Desmopressin acetate (16679-58-6 free base) (DDAVP) is the synthetic analog of the antidiuretic hormone arginine vasopressin. Vasopressin Receptor The antidiuretic properties of desmopressin have led to its use in polyuric conditions including primary nocturnal enuresis, nocturia, and diabetes insipidus. Desmopressin acetate (16679-58-6 free base) works by limiting the amount of water that is eliminated in the urine. Desmopressin acetate (16679-58-6 free base) binds to V2 receptors in renal collecting ducts, increasing water reabsorption. It also stimulates the release of von Willebrand factor from endothelial cells by acting on the V2 receptor.
SynonymsDesmopressin acetate, DDAVP
Chemical Properties
Molecular Weight1129.26
FormulaC48H68N14O14S2
Cas No.62288-83-9
SmilesCC(O)=O.NC(=O)CCC1NC(=O)C(Cc2ccccc2)NC(=O)C(Cc2ccc(O)cc2)NC(=O)CCSSCC(NC(=O)C(CC(N)=O)NC1=O)C(=O)N1CCCC1C(=O)NC(CCCNC(N)=N)C(=O)NCC(N)=O
Relative Density.1.56 g/cm3
Sequencedeamino-Cys(1)-Tyr-Phe-Gln-Asn-Cys(1)-Pro-D-Arg-Gly-NH2.CH3CO2H
Sequence ShortCYFQNCPRG
Storage & Solubility Information
Storagestore at low temperature,keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 125 mg/mL (110.69 mM), Sonication is recommended.
DMSO: 125 mg/mL (110.69 mM), Sonication is recommended.
Ethanol: Soluble
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM0.8855 mL4.4277 mL8.8554 mL44.2768 mL
5 mM0.1771 mL0.8855 mL1.7711 mL8.8554 mL
10 mM0.0886 mL0.4428 mL0.8855 mL4.4277 mL
20 mM0.0443 mL0.2214 mL0.4428 mL2.2138 mL
50 mM0.0177 mL0.0886 mL0.1771 mL0.8855 mL
100 mM0.0089 mL0.0443 mL0.0886 mL0.4428 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

VasopressinReceptorVasopressin receptor 2vasopressin receptor 1aVasopressin receptor 1Vasopressin ReceptorDesmopressin acetate (16679586 free base)Desmopressin acetate (16679 58 6 free base)Desmopressin Acetate16679-58-6 free base16679-58-6
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