Powder: -20°C for 3 years | In solvent: -80°C for 1 year
M62812 (free base), a Toll-like receptor 4 (TLR4) signal transduction inhibitor, suppresses activation of endothelial cells and leukocytes and prevents lethal septic shock in mice. It is utilized in sepsis research [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | M62812 (free base), a Toll-like receptor 4 (TLR4) signal transduction inhibitor, suppresses activation of endothelial cells and leukocytes and prevents lethal septic shock in mice. It is utilized in sepsis research [1]. |
In vitro | M62812 (0-10 μg/ml) inhibits the upregulation of inflammatory cytokines, adhesion molecules, and procoagulant activity induced by LPS in human endothelial cells and peripheral mononuclear cells [1]. |
In vivo | M62812, administered intravenously at dosages of 10-20 mg/kg as a single injection, protected mice from lethality in a d-galactosamine-sensitized endotoxin shock model, also reducing inflammatory and coagulation parameters [1]. Moreover, a daily dose of 20 mg/kg of M62812 prevented mortality in mice subjected to a cecal ligation and puncture model [1]. |
Molecular Weight | 257.31 |
Formula | C13H11N3OS |
CAS No. | 613262-61-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
M62812 free base 613262-61-6 inhibitor inhibit