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Synonyms: TERT, ILAKFLHWL


| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 µg | $147 | 7-10 days | 7-10 days | |
| 20 µg | $228 | 7-10 days | 7-10 days | |
| 50 µg | $419 | 7-10 days | 7-10 days | |
| 100 µg | $665 | 7-10 days | 7-10 days | |
| 200 µg | $1,050 | 7-10 days | 7-10 days | |
| 500 µg | $1,960 | 7-10 days | 7-10 days |
| Bioactivity | Immobilized Biotinylated Human HLA-A*11:01&B2M&EGFR WT (KITDFGLAK) Monomer, His Avi Tag at 2 μg/ml (100 μl/well) on the streptavidin precoated plate (5 μg/ml). Dose response curve for HLA-A*11:01&B2M&EGFR TCR, hFc Tag with the EC50 of 32.6 ng/ml determined by ELISA (QC Test). |
| Description | HLA-A*11:01&B2M&EGFR WT (KITDFGLAK) Monomer Protein, Human, MHC (E. coli, His & Avi), Biotinylated is expressed in E. coli. The accession number is AAV53343.1(HLA-A*11:01)&P61769(B2M)&KITDFGLAK. |
| Species | Human |
| Expression System | E. coli |
| Tag | C-His-Avi |
| Accession Number | AAV53343.1(HLA-A*11:01)&P61769(B2M)&KITDFGLAK |
| Construction | Gly25-Thr305 (HLA-A*11:01), Ile21-Met119 (B2M) and KITDFGLAK peptide |
| Protein Purity | > 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC |
| Endotoxin | < 1 EU/μg of the protein as determined by the LAL method. |
| Formulation | Supplied as 0.22 μm filtered solution in 20 mM Tris, 200 mM NaCl (pH 8.0). |
| Synonyms | TERT, ILAKFLHWL |
| Research Background | The human telomerase catalytic subunit human telomerase reverse transcriptase (hTERT) is expressed in many human cancer cells derived from multiple tissues, but infrequently in normal cells. Thus, hTERT is an attractive candidate target for tumor immunotherapy. hTERT:540–548 peptide (p540, ILAKFLHWL) has been identified as an effective HLA-A*0201-restricted T-cell epitope, an effective T-cell-based cancer treatment, including vaccines, against hTERT will likely require the identification of other MHC class I-restricted epitopes in this antigen. |
| Molecular Weight | 35.36 kDa (HLA-A*11:01) and 11.9 kDa (B2M) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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