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Etoposide Phosphate

Name: Etoposide Phosphate
Brand: TargetMol
SKU: T21303
Rating: 4.5 (1 reviews)

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Catalog No. T21303Cas No. 117091-64-2

Alias Phosphate Vepesid VP16

Etoposide Phosphate is a selective and orally active topoisomerase II inhibitor and anticancer chemotherapy drug that inhibits cancer cell growth and induces apoptosis through DNA damage, the p53 pathway, and G2/M phase arrest of the cell cycle.

Etoposide Phosphate

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Catalog No. T21303Alias Phosphate Vepesid VP16Cas No. 117091-64-2

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	$199	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Etoposide Phosphate is a selective and orally active topoisomerase II inhibitor and anticancer chemotherapy drug that inhibits cancer cell growth and induces apoptosis through DNA damage, the p53 pathway, and G2/M phase arrest of the cell cycle.
In vitro	Method: A cell viability assay was performed using HCT116 FBXW+/+, FBXW-/-, and p53-/- cell lines. Cells were treated with various concentrations of Etoposide Phosphate (0.025, 0.05, 0.075, 0.1, 0.2, 0.4, 0.6, 0.8, and 1 μM) and incubated for 72 hours to evaluate its effect on cell growth inhibition. Result: Etoposide Phosphate inhibited the growth of HCT116 FBXW+/+, FBXW-/-, and p53-/- cells in a concentration-dependent manner. [2]
In vivo	Method: Female CD-1 mice were administered a single intravenous dose of Etoposide Phosphate at 50, 100, or 150 mg/kg. Result: At all dose levels, light microscopy revealed degeneration of dorsal root ganglion cells, as well as axonal degeneration of their distal and proximal processes in peripheral nerves, dorsal spinal roots, and the dorsal funiculi of the spinal cord. [3]
Synonyms	Phosphate Vepesid VP16

Chemical Properties

Molecular Weight	668.54
Formula	C₂₉H₃₃O₁₆P
Cas No.	117091-64-2
Smiles	O=C1[C@@]2([C@@H](C=3C([C@@H](O[C@@H]4O[C@]5([C@]([C@H](O)[C@H]4O)(O[C@H](C)OC5)[H])[H])[C@]2(CO1)[H])=CC6=C(C3)OCO6)C7=CC(OC)=C(OP(=O)(O)O)C(OC)=C7)[H]
Relative Density.	1.55 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (119.66 mM), Sonication is recommended.

H2O: 2 mg/mL (2.99 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL (7.48 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4958 mL	7.4790 mL	14.9580 mL	74.7898 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.2992 mL	1.4958 mL	2.9916 mL	14.9580 mL
10 mM	0.1496 mL	0.7479 mL	1.4958 mL	7.4790 mL
20 mM	0.0748 mL	0.3739 mL	0.7479 mL	3.7395 mL
50 mM	0.0299 mL	0.1496 mL	0.2992 mL	1.4958 mL
100 mM	0.0150 mL	0.0748 mL	0.1496 mL	0.7479 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc