KOR/DOR agonist 1

Name: KOR/DOR agonist 1
Brand: TargetMol
SKU: T210128
Rating: 4.5 (1 reviews)

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Catalog No. T210128

KOR/DOR agonist 2 is an agonist of the KOR and DOR opioid receptors, with Ki values of 0.14 nM and 0.93 nM, respectively. It exhibits significant antinociceptive effects and can cross the blood-brain barrier.

KOR/DOR agonist 1

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Catalog No. T210128

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Product Introduction

Bioactivity

Description	KOR/DOR agonist 2 is an agonist of the KOR and DOR opioid receptors, with Ki values of 0.14 nM and 0.93 nM, respectively. It exhibits significant antinociceptive effects and can cross the blood-brain barrier.
Targets&IC50	κ Opioid Receptor:0.14 nM (Ki)
In vitro	KOR/DOR agonist 2 (Compound 21) binds to MOR with sub-nanomolar affinity, showing a K i value of 0.20 nM. In the [35S]-GTPγS binding assay, KOR/DOR agonist 2 exhibits functional activity at KOR, MOR, and DOR, with EC 50 values of 0.04 nM, 0.58 nM, and 1.28 nM, respectively.
In vivo	At a dosage of 0.1 mg/kg administered subcutaneously, KOR/DOR agonist 2 demonstrates significant antinociceptive effects in the warm water tail immersion test.

Chemical Properties

Formula

C₂₈H₃₂N₂O₅

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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