Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BChE-IN-16 (compound 87) is a potent inhibitor of human butyrylcholinesterase (hBChE) exhibiting an inhibition concentration half-maximum (IC50) of 3.8 nM. It demonstrates low cytotoxicity and potential for central nervous system (CNS) permeability, along with unique adaptability, rendering it a valuable tool for research into Alzheimer's disease (AD).
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Description | BChE-IN-16 (compound 87) is a potent inhibitor of human butyrylcholinesterase (hBChE) exhibiting an inhibition concentration half-maximum (IC50) of 3.8 nM. It demonstrates low cytotoxicity and potential for central nervous system (CNS) permeability, along with unique adaptability, rendering it a valuable tool for research into Alzheimer's disease (AD). |
Targets&IC50 | hBCHE:3.8 nM |
In vitro | BChE-IN-16 exhibits no inhibitory activity against hAChE at IC50 values greater than 10 μM [1]. It acts as a competitive inhibitor of hBChE with a K i value of 4.04 nM [1]. Additionally, BChE-IN-16 demonstrates cytotoxic effects on the SH-SY5Y cell line, with an IC50 value of 87.0 μM, and on the HepG2 cell line, with an IC50 value of 76.0 μM [1]. |
Molecular Weight | 433.56 |
Formula | C28H32FNO2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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