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BChE-IN-16

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Catalog No. T78695

BChE-IN-16 (compound 87) is a potent inhibitor of human butyrylcholinesterase (hBChE) with an inhibition concentration half-maximum (IC50) of 3.8 nM. It demonstrates low cytotoxicity, potential for central nervous system (CNS) permeability, and unique adaptability, making it a valuable tool for Alzheimer's disease (AD) research.

BChE-IN-16

BChE-IN-16

😃Good
Catalog No. T78695
BChE-IN-16 (compound 87) is a potent inhibitor of human butyrylcholinesterase (hBChE) with an inhibition concentration half-maximum (IC50) of 3.8 nM. It demonstrates low cytotoxicity, potential for central nervous system (CNS) permeability, and unique adaptability, making it a valuable tool for Alzheimer's disease (AD) research.
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Product Introduction

Bioactivity
Description
BChE-IN-16 (compound 87) is a potent inhibitor of human butyrylcholinesterase (hBChE) with an inhibition concentration half-maximum (IC50) of 3.8 nM. It demonstrates low cytotoxicity, potential for central nervous system (CNS) permeability, and unique adaptability, making it a valuable tool for Alzheimer's disease (AD) research.
Targets&IC50
BCHE (human):3.8 nM
In vitro
BChE-IN-16 exhibits no inhibitory activity against hAChE at IC50 values greater than 10 μM [1]. It acts as a competitive inhibitor of hBChE with a K i value of 4.04 nM [1]. Additionally, BChE-IN-16 demonstrates cytotoxic effects on the SH-SY5Y cell line, with an IC50 value of 87.0 μM, and on the HepG2 cell line, with an IC50 value of 76.0 μM [1].
Chemical Properties
Molecular Weight433.56
FormulaC28H32FNO2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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2 Enter the in vivo formulation:
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