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BRD4 Inhibitor-15
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Catalog No. T61327Cas No. 2761366-60-1
BRD4 Inhibitor-15 (compound 13) is a highly potent and specific BRD4 inhibitor with an IC50 of 18 nM, inducing apoptosis in 22RV1 cells by regulating Bcl-2/Bax proteins and activating caspase-3 signaling, and down-regulating c-Myc levels, making it valuable for prostate cancer research [1].
BRD4 Inhibitor-15
😃Good
Catalog No. T61327Cas No. 2761366-60-1
BRD4 Inhibitor-15 (compound 13) is a highly potent and specific BRD4 inhibitor with an IC50 of 18 nM, inducing apoptosis in 22RV1 cells by regulating Bcl-2/Bax proteins and activating caspase-3 signaling, and down-regulating c-Myc levels, making it valuable for prostate cancer research [1].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $2,140 | 6-8 weeks | 6-8 weeks | |
| 50 mg | $2,785 | 6-8 weeks | 6-8 weeks | |
| 100 mg | $3,520 | 6-8 weeks | 6-8 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | BRD4 Inhibitor-15 (compound 13) is a highly potent and specific BRD4 inhibitor with an IC50 of 18 nM, inducing apoptosis in 22RV1 cells by regulating Bcl-2/Bax proteins and activating caspase-3 signaling, and down-regulating c-Myc levels, making it valuable for prostate cancer research [1]. |
| Targets&IC50 | BRD4(1):18 ± 1.1 nM |
| In vitro | BRD4 Inhibitor-15 (also known as compound 13) demonstrates significant anti-proliferative effects on both enzalutamide-resistant 22RV1 cells and LNCap cells. Specifically, it exhibits half-maximal inhibitory concentration (IC50) values of 8.27 ± 0.28 μM and 7.33 ± 0.49 μM for each cell line, respectively [1]. |
| Molecular Weight | 359.42 |
| Formula | C22H21N3O2 |
| Cas No. | 2761366-60-1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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