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IDO-IN-1

Name: IDO-IN-1
Brand: TargetMol
SKU: T7181
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7181Cas No. 914638-30-5

IDO-IN-1 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with IC50 values of 59 nM for human IDO enzymatic activity and 12 nM for HeLa cell assays.

IDO-IN-1

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Purity: 99.91%

Catalog No. T7181Cas No. 914638-30-5

IDO-IN-1 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with IC50 values of 59 nM for human IDO enzymatic activity and 12 nM for HeLa cell assays.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$47	In Stock	In Stock
5 mg	$103	In Stock	In Stock
10 mg	$166	In Stock	In Stock
25 mg	$298	In Stock	In Stock
50 mg	$449	In Stock	In Stock
100 mg	$630	In Stock	In Stock
200 mg	$848	-	In Stock
1 mL x 10 mM (in DMSO)	$118	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.91%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	IDO-IN-1 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with IC50 values of 59 nM for human IDO enzymatic activity and 12 nM for HeLa cell assays.
Targets&IC50	IDO (HeLa cells):12 nM, IDO (human):59 nM
In vitro	IDO-IN-1 is inactive against tryptophan 2,3-dioxygenase (TOD; IC50 > 10 μM).

Chemical Properties

Molecular Weight	316.09
Formula	C₉H₇BrFN₅O₂
Cas No.	914638-30-5
Smiles	Nc1nonc1\C(Nc1ccc(F)c(Br)c1)=N\O
Relative Density.	2.03 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 682 mg/mL (2157.61 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (15.82 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1637 mL	15.8183 mL	31.6366 mL	158.1828 mL
5 mM	0.6327 mL	3.1637 mL	6.3273 mL	31.6366 mL
10 mM	0.3164 mL	1.5818 mL	3.1637 mL	15.8183 mL
20 mM	0.1582 mL	0.7909 mL	1.5818 mL	7.9091 mL
50 mM	0.0633 mL	0.3164 mL	0.6327 mL	3.1637 mL
100 mM	0.0316 mL	0.1582 mL	0.3164 mL	1.5818 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc