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Tubulin polymerization-IN-45
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Catalog No. T79341
Tubulin polymerization-IN-45, a tubulin-targeting agent, inhibits tubulin polymerization by binding to tubulin's colchicine site, inducing apoptotic cell death in hepatocellular cancer (HCC) cells [1].
Tubulin polymerization-IN-45
Tubulin polymerization-IN-45
😃Good
Catalog No. T79341
Tubulin polymerization-IN-45, a tubulin-targeting agent, inhibits tubulin polymerization by binding to tubulin's colchicine site, inducing apoptotic cell death in hepatocellular cancer (HCC) cells [1].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | Tubulin polymerization-IN-45, a tubulin-targeting agent, inhibits tubulin polymerization by binding to tubulin's colchicine site, inducing apoptotic cell death in hepatocellular cancer (HCC) cells [1]. |
| In vitro | Tubulin polymerization-IN-45 (compound 18) demonstrates effective activity against hepatocellular carcinoma (HCC) cell lines, with IC50 values ranging from 0.6 to 2.9 μM. It also exhibits moderate inhibitory activity on microtubule polymerization (IC50 = 19 μM). Furthermore, Tubulin polymerization-IN-45 causes cell cycle arrest at the G2/M phase in Huh7 and Mahlavu cells and induces apoptosis in HCC cells [1]. |
| Molecular Weight | 362.38 |
| Formula | C20H18N4O3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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