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RMC-9805

Name: RMC-9805
Brand: TargetMol
SKU: T78212
Price: 129 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: Zoldonrasib, KRAS G12D inhibitor 18, KRAS G12D IN 18) Copy Product Info

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Synonyms: Zoldonrasib, KRAS G12D inhibitor 18, KRAS G12D IN 18

Catalog No. T78212 Copy Product Info

Purity: 99.99%

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RMC-9805 (Zoldonrasib) is a mutant-selective covalent KRAS G12D inhibitor with oral activity and significant antitumor activity, inducing tumor cell apoptosis in preclinical models of various KRAS-mutant cancers.

Cas No. 2922732-54-3

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Pack Size	Price	USA Stock	Global Stock
1 mg	$129	In Stock	In Stock
5 mg	$328	In Stock	In Stock
10 mg	$511	In Stock	In Stock
25 mg	$837	In Stock	In Stock
50 mg	$1,220	In Stock	In Stock
100 mg	$1,800	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$723	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.99%

Appearance:Solid

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COA HNMR LCMS（现配现做）

Product Introduction

Bioactivity

Description	RMC-9805 (Zoldonrasib) is a mutant-selective covalent KRAS G12D inhibitor with oral activity and significant antitumor activity, inducing tumor cell apoptosis in preclinical models of various KRAS-mutant cancers.
Targets & IC50	pERK (AsPC-1 cells):23 nM (EC50), pERK (HPAC cells):7 nM, pERK (HPAC cells):7 nM (EC50)
In vitro	Methods:eCT26 (KRASG12D/G12D) and KPCY 6499c4 (KRASG12D/+) cells were treated with RMC-9805 (100 nM) for 48 h; cytokine levels were measured by cytokine array, and cell surface expression was detected by flow cytometry. Results: CXCL1 and GM-CSF were decreased, PD-L1 and PVR were decreased; CXCL10 and CCL17 were increased, MHC-I and MHC-II were increased in eCT26 (KRASG12D/G12D) and KPCY 6499c4 (KRASG12D/+) cells. [1]
In vivo	METHODS: To detect in vivo anti-tumor activity, RMC-9805 (100 mg/kg) was orally administered to eCT26 (KRASG12D/G12D) xenograft tumor mice once a day for 4-8 days. RESULTS: RMC-9805 exhibits anti-tumor activity in the KRAS G12D xenograft model. [2]
Synonyms	Zoldonrasib, KRAS G12D inhibitor 18, KRAS G12D IN 18

Chemical Properties

Molecular Weight	1168.44
Formula	C₆₃H₈₈F₃N₁₁O₇
Cas No.	2922732-54-3
Smiles	O=C1OCC(C)(C)CC=2C3=CC(=CC=C3N(C2C4=CC(=CN=C4C(OC)C)N5CCN(CC5)C6CC6)CC(F)(F)F)N7CCOC(C7)CC(NC(=O)C(N8CCC9(CN(C(=O)C%10N(C)C%10C%11CC%11)CC9)C8)C%12CCCC%12)C(=O)N%13NC1CCC%13

Storage & Solubility Information

Storage

Keep away from moisture,Store at low temperature,Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 252.5 mg/mL (216.1 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (4.28 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8558 mL	4.2792 mL	8.5584 mL	42.7921 mL
5 mM	0.1712 mL	0.8558 mL	1.7117 mL	8.5584 mL
10 mM	0.0856 mL	0.4279 mL	0.8558 mL	4.2792 mL
20 mM	0.0428 mL	0.2140 mL	0.4279 mL	2.1396 mL
50 mM	0.0171 mL	0.0856 mL	0.1712 mL	0.8558 mL
100 mM	0.0086 mL	0.0428 mL	0.0856 mL	0.4279 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.