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Telomerase-IN-2

Name: Telomerase-IN-2
Brand: TargetMol
SKU: T13115
Price: 135 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T13115Cas No. 1610878-54-0

Alias Telomerase inhibitor 2

Telomerase-IN-2 (Telomerase inhibitor 2) shows potent inhibitory activity against telomerase by decreasing the expression of dyskerin (IC50: 0.89 µM).

Telomerase-IN-2

🥰Excellent

Purity: 99.32%

Catalog No. T13115Alias Telomerase inhibitor 2Cas No. 1610878-54-0

Telomerase-IN-2 (Telomerase inhibitor 2) shows potent inhibitory activity against telomerase by decreasing the expression of dyskerin (IC50: 0.89 µM).

Pack Size	Price	Availability
1 mg	$135	In Stock
5 mg	$336	In Stock
10 mg	$493	In Stock
25 mg	$892	In Stock
50 mg	$1,330	In Stock
1 mL x 10 mM (in DMSO)	$469	In Stock

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Batch Information

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Purity:99.32%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Telomerase-IN-2 (Telomerase inhibitor 2) shows potent inhibitory activity against telomerase by decreasing the expression of dyskerin (IC50: 0.89 µM).
Targets&IC50	Telomerase:0.89 µM
In vitro	Telomerase-IN-2 exhibits high activity against Hela, SMMC-7721, SGC-7901, U87 and HepG2 cell lines in the anticancer activity assay in vitro[1].
Synonyms	Telomerase inhibitor 2

Chemical Properties

Molecular Weight	633.69
Formula	C₃₄H₃₉N₃O₉
Cas No.	1610878-54-0
Smiles	COc1cc(OC)c2c(c1)oc(-c1cc(OC)c(OC)c(OC)c1)c(OCCCCN1CCN(CC1)C(=O)c1ccncc1)c2=O
Relative Density.	1.32 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 235 mg/mL (370.84 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5781 mL	7.8903 mL	15.7806 mL	78.9029 mL
5 mM	0.3156 mL	1.5781 mL	3.1561 mL	15.7806 mL
10 mM	0.1578 mL	0.7890 mL	1.5781 mL	7.8903 mL
20 mM	0.0789 mL	0.3945 mL	0.7890 mL	3.9451 mL
50 mM	0.0316 mL	0.1578 mL	0.3156 mL	1.5781 mL
100 mM	0.0158 mL	0.0789 mL	0.1578 mL	0.7890 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc