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Topoisomerase II inhibitor 13
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Catalog No. T67899Cas No. 451515-89-2
Topoisomerase II inhibitor 13 inhibits topoisomerase II (Topo II) that shows strong anti-proliferation activity against HL-60/MX2 cancer cells derived from HL-60 against Topo II toxicity.
Topoisomerase II inhibitor 13
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Purity: 99.84%
Catalog No. T67899Cas No. 451515-89-2
Topoisomerase II inhibitor 13 inhibits topoisomerase II (Topo II) that shows strong anti-proliferation activity against HL-60/MX2 cancer cells derived from HL-60 against Topo II toxicity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $34 | - | In Stock | |
| 10 mg | $54 | - | In Stock | |
| 25 mg | $92 | - | In Stock | |
| 50 mg | $137 | - | In Stock | |
| 100 mg | $203 | - | In Stock | |
| 200 mg | $291 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.84%
Appearance:Solid
Color:Yellow
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Product Introduction
Topoisomerase II inhibitor 13 AI Summary
Topoisomerase II inhibitor 13 exhibits significant bioactivity against Plasmodium falciparum strains Dd2 and 3D7, with inhibition rates of 99.0% and 100.0% respectively in whole red blood cells. It has an XC50 value of 266.88 nM against Plasmodium falciparum 3D7 LDH activity and shows a lower inhibition rate of 2.0% in another LDH reporter assay. The compound also inhibits the human HepG2 cell line by 8.0% and demonstrates an Inhibition Frequency Index (IFI) of 5.52% in non-kinase HTS assays. Additionally, Topoisomerase II inhibitor 13 exhibits cytotoxicity against transgenic Leishmania Mexicana promastigotes with glucose transport deficiencies, showing inhibitory activity ranging from 4.63% to 7.13%. It has antiproliferative effects on various human cancer cell lines, including HeLa, MDA-MB-201, A549, K562, Raji, HL60, and HL60/MX2 cells, with IC50 values ranging from 1800.0 nM to 28900.0 nM after 48 hours of treatment. Furthermore, it displays an IC50 ratio of 2.5 when comparing its activity on HL60/MX2 cells to HL60 cells and exhibits cytotoxicity against HEK293 cells with an IC50 value of 7870.0 nM after 48 hours..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Topoisomerase II inhibitor 13 inhibits topoisomerase II (Topo II) that shows strong anti-proliferation activity against HL-60/MX2 cancer cells derived from HL-60 against Topo II toxicity. |
| Molecular Weight | 413.48 |
| Formula | C22H23N9 |
| Cas No. | 451515-89-2 |
| Smiles | NC1=C(C=2C(N1CCCN(CC)CC)=NC(C#N)=C(C#N)N2)C=3NC=4C(N3)=CC=CC4 |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 6 mg/mL (14.51 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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