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Anti-BUB1 Antibody (7B946)
😃Good
Catalog No. TMAH-00124
Alias Mitotic checkpoint serine/threonine-protein kinase BUB1, hBUB1, EC 2.7.11.1, BUB1L, BUB1A, BUB 1
Anti-BUB1 Antibody (7B946) is an antibody targeting BUB1. Anti-BUB1 Antibody (7B946) can be used in ELISA, WB.
Anti-BUB1 Antibody (7B946)
Anti-BUB1 Antibody (7B946)
😃Good
Catalog No. TMAH-00124Alias Mitotic checkpoint serine/threonine-protein kinase BUB1, hBUB1, EC 2.7.11.1, BUB1L, BUB1A, BUB 1
Anti-BUB1 Antibody (7B946) is an antibody targeting BUB1. Anti-BUB1 Antibody (7B946) can be used in ELISA, WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $208 | 7-10 days | |
| 100 μL | $349 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Rabbit Monoclonal Application: ELISA, WB Reactivity: Human |
| Alias | Mitotic checkpoint serine/threonine-protein kinase BUB1, hBUB1, EC 2.7.11.1, BUB1L, BUB1A, BUB 1 |
| Ig Type | Rabbit IgG |
| Clone | 7B946 |
| Reactivity | Human |
| Verified Activity | Western Blot -Positive WB detected in: Hela whole cell lysate, K562 whole cell lysate, HepG2 whole cell lysate -All lanes: Bub1 antibody at 1:1000 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 123, 116, 120 kDa -Observed band size: 130 kDa |
| Application | ELISA, WB |
| Recommended Dose | WB:1:500-1:5000. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Nucleus. Chromosome, centromere, kinetochore. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human Bub1 |
| Antigen Species | Human |
| Gene ID | 699 |
| Uniprot ID | |
| Biology Area | Cancer, Cell biology |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
Sci Citations
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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