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(±)11-HDHA

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Catalog No. T35505Cas No. 87018-59-5

(±)11-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. DHA is metabolized to 11(S)-HDHA by human platelets and canine retina. In addition to 11(S)-HDHA, 14(S)-HDHA is also produced by platelets. 11(S)-HDHA was shown to be an inhibitor of U-46619-induced human platelet aggregation and rabbit and rat aortic smooth muscle contraction with IC50 values of about 50, 4.7, and 7.5 μM, respectively. (±)11-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.

(±)11-HDHA

(±)11-HDHA

😃Good
Catalog No. T35505Cas No. 87018-59-5
(±)11-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. DHA is metabolized to 11(S)-HDHA by human platelets and canine retina. In addition to 11(S)-HDHA, 14(S)-HDHA is also produced by platelets. 11(S)-HDHA was shown to be an inhibitor of U-46619-induced human platelet aggregation and rabbit and rat aortic smooth muscle contraction with IC50 values of about 50, 4.7, and 7.5 μM, respectively. (±)11-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.
Pack SizePriceAvailabilityQuantity
25 μg$27935 days
50 μg$52235 days
100 μg$99035 days
250 μg$2,17035 days
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Product Introduction

Bioactivity
Description
(±)11-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. DHA is metabolized to 11(S)-HDHA by human platelets and canine retina. In addition to 11(S)-HDHA, 14(S)-HDHA is also produced by platelets. 11(S)-HDHA was shown to be an inhibitor of U-46619-induced human platelet aggregation and rabbit and rat aortic smooth muscle contraction with IC50 values of about 50, 4.7, and 7.5 μM, respectively. (±)11-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.
Chemical Properties
Molecular Weight344.495
FormulaC22H32O3
Cas No.87018-59-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
0.1 M Na2CO3: 2 mg/mL (5.81 mM), Sonication is recommended.
DMSO: Miscible
DMF: Miscible
PBS (pH 7.2): 0.8 mg/mL (2.32 mM), Sonication is recommended.
Ethanol: Miscible
Solution Preparation Table
PBS (pH 7.2)/0.1 M Na2CO3
1mg5mg10mg50mg
1 mM2.9028 mL14.5140 mL29.0280 mL145.1400 mL
0.1 M Na2CO3
1mg5mg10mg50mg
5 mM0.5806 mL2.9028 mL5.8056 mL29.0280 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

11-HDHA(±)11 HDHA(±)11HDHA
Related Tags: buy (±)11-HDHA | purchase (±)11-HDHA | (±)11-HDHA cost | order (±)11-HDHA | (±)11-HDHA chemical structure | (±)11-HDHA formula | (±)11-HDHA molecular weight
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