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StemRegenin 1 Hydrochloride
🥰Excellent
Catalog No. T23400Cas No. 2319882-01-2
Alias StemRegenin 1 (hydrochloride) (1227633-49-9 free base)
StemRegenin 1 Hydrochloride is an aryl hydrocarbon receptor (AhR) antagonist (IC₅₀ = 127 nM) that inhibits RANKL-induced osteoclast generation and differentiation while promoting the expansion of multipotent haematopoietic progenitor cells derived from human embryonic stem cells (hESCs).
StemRegenin 1 Hydrochloride
🥰Excellent
Purity: 99.94%
Catalog No. T23400Alias StemRegenin 1 (hydrochloride) (1227633-49-9 free base)Cas No. 2319882-01-2
StemRegenin 1 Hydrochloride is an aryl hydrocarbon receptor (AhR) antagonist (IC₅₀ = 127 nM) that inhibits RANKL-induced osteoclast generation and differentiation while promoting the expansion of multipotent haematopoietic progenitor cells derived from human embryonic stem cells (hESCs).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $209 | - | In Stock | |
| 5 mg | $383 | - | In Stock | |
| 10 mg | $677 | - | In Stock | |
| 25 mg | $1,060 | - | In Stock | |
| 50 mg | $1,430 | - | In Stock | |
| 100 mg | $1,930 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.94%
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Product Introduction
Bioactivity
Chemical Properties
| Description | StemRegenin 1 Hydrochloride is an aryl hydrocarbon receptor (AhR) antagonist (IC₅₀ = 127 nM) that inhibits RANKL-induced osteoclast generation and differentiation while promoting the expansion of multipotent haematopoietic progenitor cells derived from human embryonic stem cells (hESCs). |
| Targets&IC50 | AhR:127 nM |
| In vitro | Culture of mPB CD34+ cells with cytokines plus StemRegenin 1 Hydrochloride for 7 days increased the number of CD34+, CD133+, and CD90+ hematopoietic stem and progenitor cell populations 2.6-, 2.3-, and 10-fold, respectively [1]. StemRegenin 1 Hydrochloride in the absence of cytokines did not induce proliferation, and at concentrations above 1 μM, StemRegenin 1 Hydrochloride treatment is anti-proliferative [2]. |
| In vivo | Method: StemRegenin 1 Hydrochloride (30 μg/kg, administered three times per week, every other day, for 30 days) was intraperitoneally injected into mice that had undergone total-body irradiation (TBI) (irradiation dose 6 Gy) 4 hours prior, to investigate the radioprotective effects of StemRegenin 1 Hydrochloride on lethally irradiated mice. Results: StemRegenin 1 Hydrochloride alleviated the lethal effects and pancytopenia induced by total-body irradiation (TBI) in mice [3]. |
| Synonyms | StemRegenin 1 (hydrochloride) (1227633-49-9 free base) |
| Molecular Weight | 466 |
| Formula | C24H24ClN5OS |
| Cas No. | 2319882-01-2 |
| Smiles | Cl.CC(C)n1cnc2c(NCCc3ccc(O)cc3)nc(nc12)-c1csc2ccccc12 |
| Relative Density. | no data available |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: ≤ 2.5 mg/mL, Sonication is recommended. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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