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StemRegenin 1 Hydrochloride
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Catalog No. T23400Cas No. 2319882-01-2
Alias StemRegenin 1 (hydrochloride) (1227633-49-9 free base)
StemRegenin 1 Hydrochloride is an aryl hydrocarbon receptor (AhR) antagonist (IC₅₀ = 127 nM) that inhibits RANKL-induced osteoclast generation and differentiation while promoting the expansion of multipotent haematopoietic progenitor cells derived from human embryonic stem cells (hESCs).
StemRegenin 1 Hydrochloride
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Purity: 99.94%
Catalog No. T23400Alias StemRegenin 1 (hydrochloride) (1227633-49-9 free base)Cas No. 2319882-01-2
StemRegenin 1 Hydrochloride is an aryl hydrocarbon receptor (AhR) antagonist (IC₅₀ = 127 nM) that inhibits RANKL-induced osteoclast generation and differentiation while promoting the expansion of multipotent haematopoietic progenitor cells derived from human embryonic stem cells (hESCs).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $209 | - | In Stock | |
| 5 mg | $383 | - | In Stock | |
| 10 mg | $677 | - | In Stock | |
| 25 mg | $1,060 | - | In Stock | |
| 50 mg | $1,430 | - | In Stock | |
| 100 mg | $1,930 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.94%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | StemRegenin 1 Hydrochloride is an aryl hydrocarbon receptor (AhR) antagonist (IC₅₀ = 127 nM) that inhibits RANKL-induced osteoclast generation and differentiation while promoting the expansion of multipotent haematopoietic progenitor cells derived from human embryonic stem cells (hESCs). |
| Targets&IC50 | AhR:127 nM |
| In vitro | Culture of mPB CD34+ cells with cytokines plus StemRegenin 1 Hydrochloride for 7 days increased the number of CD34+, CD133+, and CD90+ hematopoietic stem and progenitor cell populations 2.6-, 2.3-, and 10-fold, respectively [1]. StemRegenin 1 Hydrochloride in the absence of cytokines did not induce proliferation, and at concentrations above 1 μM, StemRegenin 1 Hydrochloride treatment is anti-proliferative [2]. |
| In vivo | Method: StemRegenin 1 Hydrochloride (30 μg/kg, administered three times per week, every other day, for 30 days) was intraperitoneally injected into mice that had undergone total-body irradiation (TBI) (irradiation dose 6 Gy) 4 hours prior, to investigate the radioprotective effects of StemRegenin 1 Hydrochloride on lethally irradiated mice. Results: StemRegenin 1 Hydrochloride alleviated the lethal effects and pancytopenia induced by total-body irradiation (TBI) in mice [3]. |
| Synonyms | StemRegenin 1 (hydrochloride) (1227633-49-9 free base) |
| Molecular Weight | 466 |
| Formula | C24H24ClN5OS |
| Cas No. | 2319882-01-2 |
| Smiles | Cl.CC(C)n1cnc2c(NCCc3ccc(O)cc3)nc(nc12)-c1csc2ccccc12 |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: ≤ 2.5 mg/mL, Sonication is recommended. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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