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Incensole acetate

Name: Incensole acetate
Brand: TargetMol
SKU: TN1764
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN1764Cas No. 34701-53-6

Incensole acetate is a natural product and TRPV3 agonist that induces calcium influx in HEK293 cells expressing TRPV3 channels. It modifies c-Fos activation in the mouse brain, exhibits anti-anxiety effects, and possesses anti-inflammatory properties.

Incensole acetate

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Purity: 98.32%

Catalog No. TN1764Cas No. 34701-53-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$52	In Stock	In Stock
5 mg	$110	In Stock	In Stock
10 mg	$190	-	In Stock
25 mg	$379	-	In Stock
50 mg	$569	-	In Stock
1 mL x 10 mM (in DMSO)	$85	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.32%

Appearance:Oil

Color:Transparent

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Incensole acetate is a natural product and TRPV3 agonist that induces calcium influx in HEK293 cells expressing TRPV3 channels. It modifies c-Fos activation in the mouse brain, exhibits anti-anxiety effects, and possesses anti-inflammatory properties.
Targets&IC50	HEK293 cells:2.2 μM
In vitro	Methods: To investigate the preventive effects on Aβ25-35-induced neurotoxicity in homo sapiens olfactory bulb neural stem cells (hOBNSCs), hOBNSCs were pretreated with Incensole acetate (100 μM) for 4 hours prior to Aβ25-35 treatment. Cell viability was assessed using the MTT assay.  Results: Aβ25-35 significantly reduced cell viability, whereas Incensole acetate pretreatment markedly restored cell viability.[1]

Chemical Properties

Molecular Weight	348.52
Formula	C₂₂H₃₆O₃
Cas No.	34701-53-6
Smiles	CC(C)[C@@]12CC[C@@](C)(O1)[C@H](CC\C(C)=C\CC\C(C)=C\C2)OC(C)=O
Relative Density.	0.99 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (229.54 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (9.47 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8693 mL	14.3464 mL	28.6928 mL	143.4638 mL
5 mM	0.5739 mL	2.8693 mL	5.7386 mL	28.6928 mL
10 mM	0.2869 mL	1.4346 mL	2.8693 mL	14.3464 mL
20 mM	0.1435 mL	0.7173 mL	1.4346 mL	7.1732 mL
50 mM	0.0574 mL	0.2869 mL	0.5739 mL	2.8693 mL
100 mM	0.0287 mL	0.1435 mL	0.2869 mL	1.4346 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc