Shopping Cart
Remove All
Your shopping cart is currently empty
Anti-Angiotensinogen Antibody (8W147)
(Synonyms: angiotensinogen (serpin peptidase inhibitor, clade A, member 8)) Copy Product Info
🥰Excellent
Synonyms: angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Catalog No. TMAY-01434 Copy Product Info
🥰Excellent
Anti-Angiotensinogen Antibody (8W147) is a Rabbit antibody targeting Angiotensinogen. Anti-Angiotensinogen Antibody (8W147) can be used in ELISA,FCM,ICC/IF,IP,WB.
Anti-Angiotensinogen Antibody
(8W147)
(8W147)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 100 μL | $269 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
Add to Cart
Add to Quotation
For research use only—not for human use. No sales to individuals. Use as intended only.
Resource Download
Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-Angiotensinogen Antibody (8W147) is a Rabbit antibody targeting Angiotensinogen. Anti-Angiotensinogen Antibody (8W147) can be used in ELISA,FCM,ICC/IF,IP,WB. |
| Synonyms | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
| Ig Type | Rabbit IgG |
| Clone | 8W147 |
| Reactivity | Human |
| Specificity | Human Angiotensinogen No cross-reactivity in ELISA with Human SerpinA1 / A1AT Human SerpinA3 / SERPINA3 / AACT Human SerpinA5 / C inhibitoR Human SerpinD1 / HC2 Human SerpinF2 / SERPINF2 Human SerpinG1 / C1IN Human SerpinI1 / Protease inhibitor 12 Human SerpinC1 /SERPINC1/ Antithrombin-III |
| Application | |
| Recommended Dose | WB: 1:500-1:2000; ELISA: 1:5000-1:10000; ICC-IF: 1:20-1:100; FCM: 1:25-1:100; IP: 4-6 μL/mg of lysate |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human SerpinA8 / angiotensinogen (rh SerpinA8; TMPY-01232; NP_000020.1; Met 1-Ala 485). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Angiotensinogen, also known as AGT and SerpinA8, is a member of the serpin family. It is an α-2-globulin that is produced constitutively and released into the circulation mainly by the liver. Angiotensinogen is a essential component of the renin-angiotensin system (RAS) and a potent regulator of blood pressure. Angiotensinogen can be schematically considered to consist of a combination of an angiotensin I (Ang I) function, located at the N-terminal end, and the presence of a serpin (serine protease inhibitor) structure at the opposite end. Angiotensinogen is cleaved into three chains: Angiotensin-1 (Ang I), Angiotensin-2 (Ang II), and Angiotensin-3 (Ang III). Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-7 is cleaved from angiotensin-2 by ACE2. Angiotensin-2 acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system. Defects in AGT are associated with susceptibility to essential hypertension and renal tubular dysgenesis (RTD). Several serpins (antithrombin, maspin, pigment epithelial-derived factor, and kallistatin) have been recently shown to exert an antiangiogenic activity, suggesting a common mechanism of endothelial cell proliferation and migration. Angiotensinogen/AGT and its renin-cleaved product, des(Ang I)AGT, are also angiogenesis inhibitors, both in vitro and in vivo at concentrations within the range of those observed in plasma. The Angiotensinogen products, that is angiotensin II and possibly angiotensin II-related products, have been found to act locally in modulating adipose tissue growth in an autocrine/paracrine manner. The transient or chronic overexpression of angiotensinogen in adipose tissue favors lipogenesis in adipocytes and leads to a 'vicious' circle whereby adipose tissue development is further increased. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human SerpinA8 protein (TMPY-01232) |
| Antigen Species | Human |
| Biology Area | Serine Proteases and Regulators |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
Calculator
Preview
Related Tags:
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.