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Sufotidine

Catalog No. T68146 CAS 80343-63-1

Synonyms: AH 25352X, AH25352X, AH-25352X

Sufotidine (AH 25352X) is a highly selective competitive H2 receptor antagonist.

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Sufotidine, CAS 80343-63-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 250.00
5 mg	In stock	$ 623.00
10 mg	In stock	$ 887.00
25 mg	In stock	$ 1,330.00
50 mg	In stock	$ 1,780.00

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Purity: 100%

Purity: 99.28%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Sufotidine (AH 25352X) is a highly selective competitive H2 receptor antagonist.

In vitro

The acid inhibitory effect of sufotidine, a potent, long-lasting, competitive H2-receptor antagonist, was studied in 12 healthy males in a double-blind, randomized, three-way cross-over study of the effect of placebo, sufotidine 600 mg nocte and sufotidine 600 mg b.d. given over 15 days. On days 1 and 15 of dosing with each regimen, each subject's 24-hour ambulatory intragastric acidity was measured by radiotelemetry, and 24-hour plasma gastrin profiles were derived from hourly venous blood samples. Acid suppression was calculated as the decrease in the area under the curve of hydrogen ion activity vs time from that observed on placebo, and 24-h plasma gastrin was calculated as the area under the curve of plasma gastrin concentration vs time. 24h intragastric acidity during the fifteenth day of dosing with sufotidine 600 mg nocte and sufotidine 600 mg b.d. did not differ significantly, but on the first and fifteenth day of dosing nocturnal acidity was decreased to a greater extent by sufotidine 600 mg nocte than sufotidine 600 mg b.d. (P less than 0.005). After 15 days, the acid suppression afforded by sufotidine 600 mg b.d. was significantly attenuated (P less than 0.0005); this was associated with a rise in 24-h plasma gastrin (P less than 0.001). Thus, tolerance to the acid-inhibitory effect of H2-receptor antagonists exists and is of rapid onset.[1]

Synonyms	AH 25352X, AH25352X, AH-25352X
Molecular Weight	421.56
Formula	C20H31N5O3S
CAS No.	80343-63-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (130.47 mM)

References and Literature

1. Rogers MJ, et al. The effects of 15 days of dosing with placebo, sufotidine 600 mg nocte or sufotidine 600 mg twice daily upon 24-hour intragastric acidity and 24-hour plasma gastrin. Aliment Pharmacol Ther. 1990;4 Suppl 1:65-74. 2. Johnston DA, et al. Inhibition of gastric secretion following single morning or twice daily oral administration of sufotidine to volunteers. Br J Clin Pharmacol. 1989 Oct;28(4):403-7.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library GPCR Compound Library Bioactive Compound Library Bioactive Compounds Library Max

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Keywords

Sufotidine 80343-63-1 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor AH 25352X AH25352X AH-25352X inhibitor inhibit

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